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Penicillin Combinations WHO AWaRe: Access Prescription only

Ampicillin Sulbactam (Unasyn) — Compare Prices at US & Canada Pharmacies

Compare real Ampicillin Sulbactam prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.

Generic name Ampicillin Sulbactam
Also sold as
Unasyn
Drug class
Penicillin Combinations
Common forms
Injectable (reconstituted)
Generic available
Yes
Legal status
Prescription only

What is the typical price of Ampicillin-Sulbactam Sodium without insurance coverage?

Uninsured patients typically face a retail price of around $78.52 per 8, 3 (2-1)gm solution reconstituted for Ampicillin-Sulbactam Sodium. However, lower prices may be accessible by using pharmacy discount cards or manufacturer coupons—many programs can reduce this cost significantly. Because Ampicillin-Sulbactam Sodium is the generic version rather than the brand-name Unasyn, it generally costs far less than its brand-name counterpart.

How much does Ampicillin-Sulbactam Sodium cost when covered by health insurance?

Out-of-pocket costs depend entirely on your specific insurance plan, as formularies vary widely between providers and policies. Your copay, coinsurance, or deductible will determine what you actually pay at the pharmacy. To find your coverage details and any associated costs, contact your insurance company directly. If Ampicillin-Sulbactam Sodium is not covered under your plan, or if your out-of-pocket cost is high, discount programs and pharmacy price-comparison tools can help you find more affordable pricing options. These options may also be available to Medicare and Medicaid beneficiaries when coverage is limited or incomplete.

What brand name is Ampicillin-Sulbactam Sodium sold under?

Unasyn is the brand-name formulation of Ampicillin-Sulbactam Sodium. The generic version is substantially more affordable—often costing significantly less—while containing identical active ingredients to the brand product.

Ampicillin Sulbactam prices at US pharmacies

(Ampicillin-Sulbactam Sodium) — solution reconstituted, 3 (2-1)gm, qty 8

PharmacyRetail priceWith discount card
Walgreens Lowest $34.40 $31.40
CVS Pharmacy $36.82 $33.82
Publix $71.73 $68.73
Kroger Pharmacy $91.50 $88.50
Harris Teeter Pharmacy $91.50 $88.50
Walmart Neighborhood Market $100.44 $97.44
Walmart Pharmacy $100.44 $97.44

Unasyn (Ampicillin-Sulbactam Sodium) — solution reconstituted, 3 (2-1)gm, qty 1

PharmacyRetail priceWith discount card
Walgreens Lowest $34.40 $31.40
CVS Pharmacy $36.82 $33.82
Publix $71.73 $68.73
Kroger Pharmacy $91.50 $88.50
Harris Teeter Pharmacy $91.50 $88.50
Walmart Neighborhood Market $100.44 $97.44
Walmart Pharmacy $100.44 $97.44

Ampicillin Sulbactam prices at Canadian pharmacies

No Canadian pharmacy pricing was found for Ampicillin Sulbactam in our latest data pull.

Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.

What is Ampicillin Sulbactam used for?

Ampicillin-Sulbactam Sodium is a penicillin combination antibiotic produced by Eugia US LLC. The typical retail price without insurance is $78.52 per 8, 3 (2-1)gm solution reconstituted, though discounted pricing options may be available through various coupon and pharmacy discount programs. This is a generic medication; Unasyn is the brand-name equivalent of Ampicillin-Sulbactam Sodium.

Available forms

solution reconstituted

Related & alternative drugs

Warnings & interactions

This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.

Contraindications

CONTRAINDICATIONS The use of ampicillin and sulbactam for injection is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins).

Warnings

WARNINGS Hypersensitivity Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients on penicillin therapy. These reactions are more apt to occur in individuals with a history of penicillin hypersensitivity and/or hypersensitivity reactions to multiple allergens. There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe reactions when treated with cephalosporins. Before therapy with a penicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, and other allergens.

Known drug interactions

Drug Interactions: Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Concurrent use of probenecid with ampicillin and sulbactam for injection may result in increased and prolonged blood levels of ampicillin and sulbactam. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. There are no data with ampicillin and sulbactam for injection and allopurinol administered concurrently.

Pregnancy & breastfeeding

Pregnancy: Reproduction studies have been performed in mice, rats, and rabbits at doses up to ten (10) times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to ampicillin and sulbactam for injection. There are, however, no adequate and well-controlled studies in pregnant women.

Ampicillin Sulbactam, by the numbers

Additional public data points beyond retail pricing — useful context, not a price quote.

$2.8M
Medicare Part D spend, 2024
20.5K
Medicare Part D claims, 2024
13
FDA-listed manufacturers (Orange Book)
$5.03
Federal (VA) contract price per pack (10)

Frequently asked questions

How much does Ampicillin Sulbactam cost without insurance?
Retail (no-insurance) prices we found for Ampicillin Sulbactam range up to about $100.44 depending on pharmacy, form, and quantity. With a free pharmacy discount card, the lowest price we found was $31.40. Your actual price depends on the exact strength, quantity, and pharmacy — see the tables above.
Is there a generic version of Ampicillin Sulbactam?
Yes — our pricing data includes at least one generic listing for Ampicillin Sulbactam. Generics contain the same active ingredient and are typically the lowest-cost option; check the price tables above for the generic rows specifically.
What drug class is Ampicillin Sulbactam in?
Ampicillin Sulbactam belongs to the penicillin combinations class of antibiotics. WHO classifies it as an 'Access' antibiotic under its AWaRe stewardship framework.

Sources

Page info

Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.