Avycaz — Compare Prices at US & Canada Pharmacies
Compare real Avycaz prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the out-of-pocket cost for Avycaz without coverage?
Uninsured patients typically pay around $1,446.98 for a full course of three 2.5 gm reconstituted solution vials at the cash price, though exact costs can differ between hospitals and clinics. Patients without insurance should contact the facility where they will receive their infusion to confirm current pricing. Discount cards and manufacturer programs may lower this cost; ask your provider about available options.
What will Avycaz cost with health insurance?
Your out-of-pocket expense depends on your specific insurance plan and the facility's negotiated rate. Avycaz is often classified as a medical benefit rather than a prescription drug benefit, which can affect how your plan covers it and what you pay. Contact your insurance company directly to understand your coverage and expected costs. The clinic or hospital administering the infusion can also provide details on what your plan will cover.
Is Avycaz covered by Medicare, and what are the costs?
Medicare typically covers Avycaz under Part B as a medical benefit rather than through Part D prescription drug plans or Medicare Advantage pharmacy benefits. Since coverage structures vary, speak with your Medicare representative or agent to clarify your specific coverage details. The facility providing your infusion can also help explain how your Medicare coverage applies to Avycaz.
Are there generic versions of Avycaz available?
No generic form of Avycaz currently exists. Avycaz is a brand-name combination medication containing ceftazidime and avibactam, and no generic equivalent has been approved or released to date.
Avycaz prices at US pharmacies
Avycaz — solution reconstituted, 2.5 (2-0.5)gm, qty 3
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $1310.21 | $1307.21 |
| Harris Teeter Pharmacy | $1310.21 | $1307.21 |
| Walgreens | $1376.02 | $1373.02 |
| CVS Pharmacy | $1376.62 | $1373.62 |
| Publix | $1385.27 | $1382.27 |
| Walmart Neighborhood Market | $1406.81 | $1403.81 |
| Walmart Pharmacy | $1406.81 | $1403.81 |
| Costco | $1414.30 | $1411.30 |
Avycaz prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Avycaz in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Avycaz used for?
Avycaz combines ceftazidime, a well-established cephalosporin antibiotic, with avibactam, a newer beta-lactamase inhibitor — and it's classified under the WHO AWaRe framework as a Reserve antibiotic, the category set aside for last-resort drugs used against multidrug-resistant bacteria. It's FDA-approved for complicated intra-abdominal infections (given together with metronidazole), complicated urinary tract infections including pyelonephritis, and hospital-acquired or ventilator-associated bacterial pneumonia.
Avibactam is the reason Avycaz works where older cephalosporins fail: it blocks a wide range of beta-lactamase enzymes — including some produced by carbapenem-resistant Enterobacteriaceae (CRE) — that would otherwise destroy ceftazidime before it can act. That makes Avycaz one of the options clinicians reach for when cultures show a gram-negative organism that has become resistant to first-line antibiotics.
Because of its Reserve status, Avycaz is meant to be used only when a resistant infection is confirmed or strongly suspected — not as a routine first choice — both to protect patients from a drug with a narrower long-term safety track record and to help slow the spread of further antibiotic resistance. It's given exclusively as an IV infusion, almost always in a hospital setting, with the dose adjusted for kidney function.
How Avycaz works
Ceftazidime attacks the cell wall
Like other beta-lactams, it blocks the enzymes bacteria use to build their protective cell wall.
Avibactam disables the bacteria's defense
It inhibits beta-lactamase enzymes — including several linked to carbapenem resistance — that would otherwise break ceftazidime down.
The bacterial cell fails
With cell-wall construction blocked and ceftazidime protected from destruction, the bacterium ruptures and dies.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| cIAI, cUTI, HABP/VABP (adults, normal kidney function) | 2.5 g (2 g ceftazidime / 0.5 g avibactam) IV every 8 hours, infused over 2 hours | IV infusion |
| Dosing with reduced kidney function | Dose and/or interval reduced based on creatinine clearance | IV infusion |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Commonly used for
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Infusion-site pain, irritation, or redness
- Nausea, vomiting, or constipation
- Headache
Serious — seek care promptly
- Seizures (risk increases with impaired kidney function and inadequate dose adjustment)
- Severe or watery diarrhea (possible C. diff colitis)
- Signs of an allergic reaction: hives, swelling, difficulty breathing — cross-reactivity is possible in people with a penicillin allergy
Contraindications
4 CONTRAINDICATIONS AVYCAZ is contraindicated in patients with known serious hypersensitivity to the components of AVYCAZ (ceftazidime and avibactam), avibactam containing products, or other members of the cephalosporin class [see Warnings and Precautions ( 5.2 )] . AVYCAZ is contraindicated in patients with known serious hypersensitivity to the components of AVYCAZ (ceftazidime and avibactam), avibactam-containing products or other members of the cephalosporin class. ( 4 )
Notable drug interactions
| Drug / substance | What can happen |
|---|---|
| Probenecid | Inhibits the transporters that clear avibactam, potentially reducing its elimination; co-administration isn't recommended. |
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary There are no adequate and well-controlled studies of AVYCAZ, ceftazidime, or avibactam in pregnant women. Neither ceftazidime nor avibactam were teratogenic in rats at doses 40 and 9 times the recommended human clinical dose. In the rabbit, at twice the exposure as seen at the human clinical dose, there were no effects on embryofetal development with avibactam. The background risk of major birth defects and miscarriage for the indicated population is unknown.
Frequently asked questions
How much does Avycaz cost without insurance?
Is there a generic version of Avycaz?
What drug class is Avycaz in?
Learn more about Avycaz
In-depth answers to common Avycaz questions, fact-checked against the sources cited in each.
What exactly is Avycaz and how does it work?
Avycaz is a prescription antibiotic combination containing ceftazidime (a cephalosporin) and avibactam, approved to treat serious bacterial infections including hospital-acquired pneumonia, complicated urinary tract infections, and complicated intra-abdominal infections. Ceftazidime kills bacteria by disrupting cell wall formation and repair—without an intact cell wall, bacteria cannot survive and the infection clears. Avibactam serves a protective function: it prevents the body's enzymes from breaking down ceftazidime prematurely, allowing the antibiotic to remain active longer and work more effectively. Avycaz is administered as an intravenous infusion, typically every eight hours over a two-hour period. The exact dosing regimen depends on the infection being treated and is determined by your healthcare provider.
What are the possible side effects of Avycaz?
Many patients experience minimal or no side effects from Avycaz. Common side effects occur at the injection site and include localized pain, irritation, redness, and tenderness. Patients may also experience nausea, vomiting, constipation, headache, abdominal discomfort, and mood or anxiety changes. More serious side effects, though uncommon, include Clostridium difficile-associated diarrhea and seizures. Allergic reactions to Avycaz are rare but can be severe, potentially including anaphylaxis (a life-threatening drop in blood pressure) or severe skin reactions requiring hospitalization. Because infusions are administered in medical settings, healthcare staff monitor patients closely during and after treatment. Report any symptoms you believe may represent an allergic reaction or other concerning reaction to your physician or nurse immediately. This is not an exhaustive list; discuss potential side effects and any medical concerns with your healthcare provider before treatment.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Kami Kim, M.D., Infectious Diseases, Global Health