Lentocilin — Compare Prices at US & Canada Pharmacies
Compare real Lentocilin prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
How much does Lentocilin cost without insurance?
Without health insurance, the typical out-of-pocket cost of Lentocilin is $137.85 per 24, 1200000unit suspension reconstituteds at standard retail pharmacy prices. Actual costs vary between pharmacies and regions. Patients without insurance may consider using a discount card or manufacturer coupon to reduce their medication costs.
How much does Lentocilin cost with insurance?
The cost of Lentocilin with insurance depends on your specific plan's formulary and coverage details. Different insurers cover different medications, and your out-of-pocket amount depends on your copay, coinsurance, or deductible. Contact your insurance provider for accurate information about whether Lentocilin is covered and what your responsibility will be. If your plan doesn't cover Lentocilin or you face a high copay, a discount card or manufacturer coupon may help lower your cost at the pharmacy.
Is generic Lentocilin available?
No generic version of Lentocilin is available. Lentocilin is a brand-name medication produced by Laboratorios Atral S.a., and it remains available only in its branded form.
Lentocilin prices at US pharmacies
Lentocilin — suspension reconstituted, 1200000unit, qty 24
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $346.52 | $343.52 |
| Harris Teeter Pharmacy | $346.52 | $343.52 |
| Walgreens | $365.03 | $362.03 |
| Publix | $368.37 | $365.37 |
| Walmart Neighborhood Market | $372.17 | $369.17 |
| Walmart Pharmacy | $372.17 | $369.17 |
| Costco | $373.76 | $370.76 |
| CVS Pharmacy | $378.14 | $375.14 |
Lentocilin prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Lentocilin in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Lentocilin used for?
Lentocilin (Laboratorios Atral) is a long-acting, injectable formulation of benzathine benzylpenicillin — the same active ingredient sold in the US as Bicillin L-A. It's a "natural" penicillin, meaning it's derived directly from the original penicillin fermentation rather than chemically modified like amoxicillin or the anti-staphylococcal penicillins, and its benzathine salt form is specifically designed to dissolve slowly from the injection site, releasing penicillin into the bloodstream over weeks rather than hours. That slow release is the entire point: a single intramuscular dose maintains therapeutic drug levels long enough to cure syphilis in one visit or provide a full month of protection against recurrent rheumatic fever, without requiring the patient to complete a multi-day oral course.
Its approved uses reflect that long-acting profile closely: group A streptococcal throat infections, all stages of syphilis (primary, secondary, latent, tertiary, and congenital), and the related endemic treponemal diseases yaws, bejel, and pinta, plus prophylaxis against rheumatic fever recurrence and the diphtheria carrier state. Because benzathine penicillin is bacteriostatic-antagonized — bacteriostatic antibiotics like tetracyclines, macrolides, or chloramphenicol can blunt its bactericidal effect by slowing the bacterial growth the penicillin needs to act on — it's not typically combined with those drug classes for the same infection.
This formulation contains lidocaine as a local anesthetic to reduce injection pain, which means it's also contraindicated in patients with a lidocaine or amide-type local anesthetic allergy, in addition to the standard penicillin hypersensitivity contraindication. As with any penicillin, it can reduce the effectiveness of hormonal contraceptives, and it can slow the kidneys' clearance of methotrexate, raising methotrexate toxicity risk if the two are combined.
How Lentocilin works
Injected as a slow-release depot
The benzathine salt is poorly soluble, so after an intramuscular injection it forms a depot that dissolves gradually into the bloodstream.
Blocks bacterial cell wall synthesis
As penicillin is released, it binds to proteins bacteria need to build their cell wall, the same core mechanism as all penicillins.
Sustained coverage from one dose
Because release continues for weeks, a single injection can clear susceptible infections like syphilis or provide ongoing protection against strep recurrence, without a multi-day oral regimen.
Available forms
suspension reconstituted
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Injection site pain or swelling
- Rash
- Nausea
Serious — seek care promptly
- Signs of a severe allergic reaction (hives, swelling, difficulty breathing)
- Signs of a lidocaine/local anesthetic allergic reaction
- Jarisch-Herxheimer reaction when treating syphilis (fever, chills, muscle aches within hours of the injection)
Contraindications
Hypersensitivity to the active substance, to other penicillin or to any of the excipients. Hypersensitivity to lidocaine or local anesthetics of the amide type.
Notable drug interactions
| Drug / substance | What can happen |
|---|---|
| Bacteriostatic antibiotics (tetracyclines, macrolides, chloramphenicol) | May antagonize penicillin's bactericidal effect |
| Hormonal contraceptives | Penicillin may reduce contraceptive effectiveness |
| Methotrexate | Penicillins can reduce renal clearance of methotrexate, increasing toxicity risk |
Frequently asked questions
How much does Lentocilin cost without insurance?
Is there a generic version of Lentocilin?
What drug class is Lentocilin in?
Page info
Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Aldon Li, M.D., FIDSA, Infectious Disease, Internal Medicine