Seysara — Compare Prices at US & Canada Pharmacies
Compare real Seysara prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical cost of Seysara without health insurance?
The average retail price of Seysara is about $1,463.07 for a 30-day supply of 100mg tablets without insurance coverage. Prescription discount programs and pharmacy discount cards may offer reduced pricing at many pharmacies nationwide, potentially lowering your actual out-of-pocket cost.
Does Medicare cover the cost of Seysara?
Medicare generally does not cover Seysara. If you are enrolled in Medicare and need this medication, you may explore prescription discount programs and coupons to help reduce your out-of-pocket expenses. Your pharmacist can help you compare available pricing options to find the most affordable choice for your prescription.
Is a generic version of Seysara available?
Seysara is a brand-name medication with the active ingredient sarecycline. Currently, no generic equivalent is available in the U.S. market. Oracea is another brand-name tetracycline antibiotic that may be considered as an alternative, though it is used for different acne indications and should only be substituted under your doctor's guidance.
Seysara prices at US pharmacies
Seysara — tablet, 100mg, qty 30
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $1098.66 | $1095.66 |
| Harris Teeter Pharmacy | $1098.66 | $1095.66 |
| Food Lion | $1148.62 | — |
| Walgreens | $1154.08 | $1151.08 |
| CVS Pharmacy | $1157.43 | $1154.43 |
| Publix | $1162.04 | $1159.04 |
| Walmart Neighborhood Market | $1179.68 | $1176.68 |
| Walmart Pharmacy | $1179.68 | $1176.68 |
Seysara prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Seysara in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Seysara used for?
Seysara (sarecycline) is a tetracycline purpose-built for acne — it was designed and studied specifically as a narrow-spectrum tetracycline, with weaker activity against the broad range of Gram-negative gut bacteria that doxycycline and minocycline affect. That narrower spectrum is the main reason it exists as a separate drug rather than prescribers just using generic doxycycline: it's meant to control acne-related inflammation and Cutibacterium acnes with less disruption to the gut microbiome and, in theory, a lower contribution to broader antibiotic resistance, since it doesn't hit as many unrelated bacterial species along the way.
It's approved for inflammatory, non-nodular moderate-to-severe acne in patients 9 and older, taken once daily, and the FDA label is explicit about its limits: efficacy beyond 12 weeks and safety beyond 12 months haven't been established, and it hasn't been evaluated as a treatment for infections at all — it's an acne drug, not a general-purpose antibiotic, despite belonging to a class that includes plenty of general-purpose ones.
As a tetracycline, it carries the class-wide warnings: permanent tooth discoloration if used during tooth development (pregnancy, infancy, childhood through age 8), photosensitivity, and intracranial hypertension risk that's compounded by concurrent use of oral retinoids like isotretinoin — the two are specifically avoided together. It also interacts with penicillins (avoided together, since bacteriostatic tetracyclines can blunt penicillin's bactericidal effect), can enhance anticoagulant effects requiring a dose adjustment, and — like other tetracyclines — has its absorption reduced by antacids and iron supplements, which should be separated from dosing by a couple of hours.
Seysara remains brand-only with no generic available, and its price reflects that — it's dramatically more expensive than generic doxycycline or minocycline, so it tends to be considered specifically when a prescriber wants tetracycline-class acne treatment with a narrower antimicrobial footprint, rather than as a routine first choice.
How Seysara works
Blocks bacterial protein synthesis
Sarecycline binds to the bacterial ribosome and prevents protein production, limiting the growth of Cutibacterium acnes in clogged pores.
Reduces inflammation
Beyond its antibacterial effect, sarecycline has anti-inflammatory properties that help calm the redness and swelling of inflammatory acne lesions.
Spares the broader gut microbiome
Its narrower spectrum means it affects fewer unrelated bacterial species than doxycycline or minocycline, which is the main reason it was developed as an acne-specific tetracycline.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| Moderate to severe inflammatory acne (9+) | Weight-based dose, taken once daily | Tablet |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Nausea
- Headache
- Photosensitivity (sunburn risk)
Serious — seek care promptly
- Signs of intracranial hypertension (severe headache, vision changes)
- Signs of a severe allergic reaction
- Esophageal irritation if not taken with enough water
Contraindications
4 CONTRAINDICATIONS SEYSARA is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. SEYSARA is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. ( 4 )
Notable drug interactions
| Drug / substance | What can happen |
|---|---|
| Oral retinoids (isotretinoin, acitretin) | Increased risk of intracranial hypertension; combination avoided |
| Penicillins | May antagonize penicillin's bactericidal effect; combination avoided |
| Anticoagulants | May enhance anticoagulant effect; dose adjustment may be needed |
| Antacids and iron preparations | Reduce sarecycline absorption; separate dosing |
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary SEYSARA, like tetracycline class drugs, may cause fetal harm, permanent discoloration of teeth, and reversible inhibition of bone growth when administered during pregnancy [see Warnings and Precautions ( 5.1 ) and Use in Specific Populations ( 8.4 ) ] . The limited available human data are not sufficient to inform a drug-associated risk for birth defects or miscarriage.
Seysara, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Seysara cost without insurance?
Is there a generic version of Seysara?
What drug class is Seysara in?
Learn more about Seysara
In-depth answers to common Seysara questions, fact-checked against the sources cited in each.
What will I pay for Seysara if I have health insurance?
Your copay or coinsurance for Seysara depends on your specific insurance plan and coverage details. Contact your insurance provider or speak with your pharmacy to determine your exact out-of-pocket responsibility. If your insurance does not cover this medication or your copay is high, prescription discount cards may provide an alternative pricing option to compare.
What is Seysara and how does it work?
Seysara is a tetracycline-class antibiotic used to treat moderate to severe acne vulgaris in patients nine years of age and older. It is taken once daily as an oral tablet. This medication is effective only against bacterial infections and will not treat viral illnesses such as the flu or common cold. Do not use Seysara if you are allergic to sarecycline or other tetracycline antibiotics, including doxycycline, minocycline, tetracycline, or tigecycline. Take Seysara exactly as prescribed by your healthcare provider, with or without food, but always with plenty of water. Complete the full course of treatment even if your acne improves, since stopping early can promote antibiotic resistance. Seysara increases your susceptibility to sunburn—wear protective clothing, a hat, and sunscreen, and limit sun exposure while taking this medication. Drink adequate fluids to reduce the risk of esophageal complications. Before starting Seysara, inform your doctor of any other medical conditions, prescription drugs, over-the-counter medications, vitamins, or supplements you are taking. If you are pregnant or planning to become pregnant, notify your doctor immediately, as Seysara can affect fetal bone and tooth development and cause permanent tooth discoloration in the child. Do not breastfeed while using this medication, as it can pass into breast milk and affect your infant's bone and tooth development.
What side effects can Seysara cause?
Nausea is the most commonly reported side effect of Seysara. Other side effects may occur. For a complete list of possible adverse effects and more detailed safety information, consult your doctor or pharmacist. You can also report any side effects to the FDA through their MedWatch program.
Page info
Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Angelica Balingit, M.D., Internal Medicine