Sivextro — Compare Prices at US & Canada Pharmacies
Compare real Sivextro prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost for Sivextro without insurance coverage?
Without insurance, Sivextro typically costs around $3,990.02 at most pharmacies. However, patients may reduce this cost by exploring available discount programs or comparing prices across different pharmacies. Many prescription discount cards and manufacturer savings programs can help lower the final price at the point of sale.
How much might patients pay for Sivextro if they have insurance?
Sivextro costs with insurance depend on your specific plan's formulary status, copay tier, and deductible. The medication carries an average retail price of $3,990.02 per 7-pack of 200mg tablets. Your out-of-pocket cost may differ from the uninsured price, and it's worth comparing your insurance copay against available discount options. Ask your pharmacist to help you identify the most affordable option for your particular situation.
Do Medicare plans cover Sivextro, and what are typical patient costs?
Coverage for Sivextro varies among Medicare plans, and beneficiaries may encounter substantial copayments where coverage exists. Those enrolled in a Medicare plan that does cover Sivextro should verify their specific out-of-pocket responsibility before filling a prescription. Prescription discount cards may offer an alternative pricing option worth exploring with your pharmacist.
Is a generic version of Sivextro available?
Sivextro is available only as a brand-name medication. No generic formulation has been approved or is currently available in the United States market.
Sivextro prices at US pharmacies
Sivextro — tablet, 200mg, qty 7
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $3366.24 | $3363.24 |
| Harris Teeter Pharmacy | $3366.24 | $3363.24 |
| CVS Pharmacy | $3507.36 | $3504.36 |
| Food Lion | $3527.95 | — |
| Walgreens | $3533.63 | $3530.63 |
| Publix | $3555.59 | $3552.59 |
| Walmart Neighborhood Market | $3615.22 | $3612.22 |
| Walmart Pharmacy | $3615.22 | $3612.22 |
Sivextro prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Sivextro in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Sivextro used for?
Sivextro (tedizolid) is a second-generation oxazolidinone — the same drug class as linezolid, and effective against the same resistant Gram-positive organisms, including MRSA — developed specifically to address some of linezolid's practical limitations. Compared with linezolid, tedizolid is dosed once daily rather than twice, treats acute bacterial skin and skin-structure infections in a shorter 6-day course versus linezolid's typical 10–14 days, and carries a substantially lower rate of the myelosuppression (low blood counts) that limits how long linezolid can safely be used. It's approved for adults and adolescents 12 and older, in both oral tablet and IV forms with the same dose for each, allowing an easy switch between the two as a patient's condition improves.
Tedizolid also appears to have less potential for the serotonin syndrome risk and monoamine oxidase inhibitor-like drug interactions that limit linezolid — dietary tyramine restrictions and interaction warnings with SSRIs, SNRIs, and other serotonergic drugs are far less emphasized for tedizolid, though some caution around serotonergic combinations is still reasonable given the drug class similarity and the fact that long-term interaction data remains more limited than for linezolid, which has been on the market far longer.
One distinct interaction is worth knowing: oral tedizolid inhibits a transport protein (BCRP) in the intestine, which can raise blood levels of certain co-administered drugs, including rosuvastatin and, more importantly, drugs with a narrow safety margin like methotrexate — a temporary interruption of the other medication is often considered during a tedizolid course specifically because of this effect. As with linezolid, low blood cell counts and, less commonly, symptoms suggesting nerve involvement (numbness, vision changes) are known risks worth monitoring, particularly with courses that extend beyond the typical 6 days.
How Sivextro works
Blocks bacterial protein synthesis
Tedizolid binds to the bacterial ribosome at an early stage of protein production, stopping bacteria from making the proteins they need to grow.
Works against resistant organisms
Its binding site is different enough from other antibiotic classes that it remains active against MRSA and other bacteria resistant to standard treatments.
The bacterial cell dies
Without functioning protein synthesis, the bacterium can't grow or repair itself, and the infection clears — typically over a shorter course than linezolid requires.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| Acute bacterial skin infections (12+) | 200 mg orally or IV once daily for 6 days | Tablet or IV infusion |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Nausea, vomiting, or diarrhea
- Headache
- Dizziness
Serious — seek care promptly
- Signs of low blood cell counts (fever, unusual bruising or bleeding, fatigue)
- Severe or persistent diarrhea (possible C. difficile infection)
- Signs of a severe allergic reaction
Contraindications
4 CONTRAINDICATIONS None None ( 4 )
Notable drug interactions
| Drug / substance | What can happen |
|---|---|
| Methotrexate, rosuvastatin, and other BCRP-transported drugs | Tedizolid can raise blood levels of these drugs by inhibiting their intestinal transport; interruption or monitoring often considered |
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary Based on animal reproduction studies, SIVEXTRO may cause fetal harm when administered to pregnant women. The available data on the use of SIVEXTRO in pregnant women are insufficient to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Advise pregnant women of the potential risks to a fetus. Fetal developmental toxicities were observed in mice and rats treated with SIVEXTRO.
Sivextro, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Sivextro cost without insurance?
Is there a generic version of Sivextro?
What drug class is Sivextro in?
Learn more about Sivextro
In-depth answers to common Sivextro questions, fact-checked against the sources cited in each.
What is Sivextro and how does it work?
Sivextro is an antibiotic used to treat acute bacterial skin infections, especially those caused by Staphylococcus aureus (staph) bacteria. The medication is ineffective against viral infections such as the common cold or influenza. Staph bacteria naturally inhabit human skin and nasal passages without typically causing harm, but can trigger serious infections if they penetrate deeper tissues, enter the bloodstream, or spread to joints, bones, heart, or lungs. Sivextro is not approved for use in children under age 12. The medication comes in two forms: oral tablets and an injectable powder. Patients must take Sivextro exactly as prescribed and complete the entire treatment course to achieve full recovery from the infection. Healthcare professionals emphasize that improper antibiotic use—including incomplete courses or misuse—accelerates the development of drug-resistant bacteria, which diminishes the medication's future effectiveness.
What side effects should patients be aware of when taking Sivextro?
Common side effects include headache, nausea, vomiting, diarrhea, and dizziness. Patients receiving injections may experience pain or bruising at the injection site. Seek emergency medical care if you develop signs of an allergic reaction such as hives, facial swelling, throat or tongue swelling, or breathing difficulty. Contact your doctor or go to the nearest emergency department if you experience watery or bloody diarrhea, severe abdominal pain, or symptoms suggesting low blood cell counts—including fever, chills, unusual fatigue, excessive bruising, or abnormal bleeding. This is not an exhaustive list of potential side effects. Discuss all known risks and benefits of Sivextro with your healthcare provider to determine whether it is appropriate for your specific health situation.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Kami Kim, M.D., Infectious Diseases, Global Health