Tigecycline (Tygacil) — Compare Prices at US & Canada Pharmacies
Compare real Tigecycline prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost for Tigecycline without health insurance?
Without insurance coverage, tigecycline can cost approximately $504.00 at retail pharmacy prices. However, several cost-reduction strategies exist. Many pharmacies offer discount programs, and comparing prices across different pharmacy locations in your area may reveal lower rates. Patients are encouraged to ask their healthcare provider about patient assistance programs or to inquire with their pharmacy about available pricing options.
How much does Tigecycline typically cost for patients with insurance?
Tigecycline costs vary significantly depending on your specific insurance plan, deductible status, and copay structure. To determine your actual out-of-pocket expense, contact your insurance provider directly with your prescription details. You can also request that your pharmacy run a price estimate based on your insurance coverage. Additionally, using available pharmacy discount cards or coupons may provide savings even when you have insurance coverage.
Is tigecycline covered by Medicare, and what would it cost?
Tigecycline is not covered by Medicare plans, meaning beneficiaries would pay the full cash price for this medication. The average cost for a dose (4, 50mg solution reconstituteds) is approximately $504.00. Medicare patients seeking to reduce costs should explore alternative options such as pharmacy discount programs, patient assistance programs offered by manufacturers, or discussing with their doctor whether other covered alternatives might be suitable for their condition.
What brand-name drug is equivalent to generic tigecycline?
Tygacil is the brand-name version of tigecycline. The generic form is manufactured by Transo-Pharm USA LLC and Rochem International Inc., among other manufacturers.
Tigecycline prices at US pharmacies
Tigecycline — solution reconstituted, 50mg, qty 4
| Pharmacy | Retail price | With discount card |
|---|---|---|
| CVS Pharmacy Lowest | $68.90 | $65.90 |
| Publix | $108.58 | $105.58 |
| Kroger Pharmacy | $147.90 | $144.90 |
| Harris Teeter Pharmacy | $147.90 | $144.90 |
| Walmart Neighborhood Market | $160.60 | $157.60 |
| Walmart Pharmacy | $160.60 | $157.60 |
| Walgreens | $206.43 | $203.43 |
Tygacil (Tigecycline) — solution reconstituted, 50mg, qty 4
| Pharmacy | Retail price | With discount card |
|---|---|---|
| CVS Pharmacy Lowest | $68.90 | $65.90 |
| Publix | $108.58 | $105.58 |
| Kroger Pharmacy | $147.90 | $144.90 |
| Harris Teeter Pharmacy | $147.90 | $144.90 |
| Walmart Neighborhood Market | $160.60 | $157.60 |
| Walmart Pharmacy | $160.60 | $157.60 |
| Walgreens | $206.43 | $203.43 |
Tigecycline prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Tigecycline in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Tigecycline used for?
Tigecycline is a generic prescription antibiotic administered by intravenous injection to treat serious bacterial infections that have not responded to other antibiotics. It belongs to the tetracycline class of antibiotics. The brand-name equivalent is Tygacil. Uninsured patients typically face retail costs around $504.00 per dose, though discount programs and pharmacy price comparisons can significantly reduce out-of-pocket expenses.
Available forms
solution reconstituted
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Boxed warning
WARNING: ALL-CAUSE MORTALITY An increase in all-cause mortality has been observed in a meta-analysis of Phase 3 and 4 clinical trials in tigecycline-treated patients versus comparator. The cause of this mortality risk difference of 0.6% (95% CI 0.1, 1.2) has not been established. Tigecycline for injection should be reserved for use in situations when alternative treatments are not suitable [see Indications and Usage ( 1.4 ), Warnings and Precautions (5.1, 5.2) and Adverse Reactions (6.1)]. WARNING: ALL-CAUSE MORTALITY See full prescribing information for complete boxed warning.
Contraindications
4 CONTRAINDICATIONS Tigecycline for injection is contraindicated for use in patients who have known hypersensitivity to tigecycline or to any of the excipients. Reactions have included anaphylactic reactions [ see Warnings and Precautions ( 5.3 ) and Adverse Reactions ( 6.2 ) ] . Known hypersensitivity to tigecycline. ( 4 )
Known drug interactions
7 DRUG INTERACTIONS Warfarin: Suitable anticoagulation test should be monitored if tigecycline for injection is administered to patients receiving warfarin. ( 7.1 ) Calcineurin Inhibitors: Serum concentrations of calcineurin inhibitors (e.g., tacrolimus, cyclosporine) should be monitored during treatment with tigecycline for injection due to risk of toxicity. ( 7.2 ) 7.1 Warfarin Prothrombin time or other suitable anticoagulation test should be monitored if tigecycline is administered with warfarin [see Clinical Pharmacology ( 12.3 )] .
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary Tigecycline for injection, like other tetracycline class antibacterial drugs, may cause permanent discoloration of deciduous teeth and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy [see Warnings and Precautions ( 5.7 , 5.8), Data, and Use in Specific Populations ( 8.4 )] .
Tigecycline, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Tigecycline cost without insurance?
Is there a generic version of Tigecycline?
What drug class is Tigecycline in?
Learn more about Tigecycline
In-depth answers to common Tigecycline questions, fact-checked against the sources cited in each.
What is tigecycline and how does it work?
Tigecycline is an FDA-approved antibiotic used to treat serious bacterial infections that have failed to respond to standard antibiotic therapy. As a tetracycline-class antibiotic, it works by inhibiting bacterial protein synthesis, effectively stopping bacterial growth. The medication is given intravenously—injected directly into a vein over 30 to 60 minutes by a healthcare professional. Tigecycline is effective only against bacterial infections; it provides no benefit for viral illnesses such as colds or influenza. Your doctor will determine the appropriate dose based on your specific medical condition, current medications, and how your infection responds to treatment. If you're receiving this medication at home, carefully follow all preparation and administration instructions from your healthcare provider. When reconstituting, gently swirl the powder—do not shake vigorously. The mixed solution should appear yellow to orange. Do not use the medication if you observe visible particles or any green discoloration. For maximum effectiveness, maintain consistent dosing intervals throughout your treatment course. Continue taking the full prescribed amount even if symptoms resolve within a few days, as premature discontinuation can allow the infection to return.
What side effects can tigecycline cause?
Mild to moderate side effects commonly reported with tigecycline include nausea, vomiting, headache, dizziness, and localized pain or swelling at the injection site. These effects often diminish as your body adjusts to the medication. Contact your healthcare provider if these symptoms persist or intensify. Serious adverse effects requiring immediate medical attention include kidney dysfunction, unusual weakness, severe abdominal pain, hearing loss or changes, irregular heartbeats, unexplained bruising or bleeding, jaundice (yellowing of skin or eyes), and dark-colored urine. Because this list does not cover all possible side effects, ask your doctor or pharmacist for comprehensive information about the potential risks and benefits specific to your situation.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.