Trimethoprim — Compare Prices at US & Canada Pharmacies
Compare real Trimethoprim prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives. Save up to 83% by comparing US pharmacy prices.
What is the typical cost of Trimethoprim without insurance coverage?
The out-of-pocket price for Trimethoprim varies based on the quantity and strength of the prescription. Without insurance, patients typically pay around $87.09 for 30, 100mg tablets at retail prices. Prescription discount cards and manufacturer coupons available at many pharmacies can substantially reduce this cost. Comparing prices across different pharmacies and using available discount programs may help lower your final price significantly.
What should I expect to pay for Trimethoprim if I have insurance?
Your Trimethoprim copay will depend on your specific insurance plan's coverage, the dosage, and quantity prescribed. Insurance copays vary widely between plans. You may want to contact your insurance provider directly to learn your exact copay amount. Many pharmacies allow you to compare your insurance copay with discount card prices before filling your prescription, so you can choose the most affordable option available to you.
Is Trimethoprim covered under Medicare, and what are the costs?
Trimethoprim is typically covered as part of Medicare prescription drug plans (Part D). Your actual out-of-pocket cost depends on your specific plan's formulary, deductible, and coverage tier. For detailed information about your coverage and costs, contact your Medicare plan directly or speak with your pharmacist. If you lack prescription drug coverage, discount pharmacy programs may provide an alternative way to reduce your medication expenses.
What brand names is Trimethoprim sold under?
Trimethoprim is available as a generic medication. Brand names previously associated with trimethoprim include Primsol, Proloprim, and Trimpex, though many of these brand formulations are no longer actively marketed or may be difficult to obtain.
"As low as" figures compare the single lowest oral tablet/capsule price found on each side — not necessarily the same strength or pack size. Always check the full tables below for your exact dose. Prices updated 2026-08-21.
Trimethoprim prices at US pharmacies
Trimethoprim — tablet, 100mg, qty 30
| Pharmacy | Retail price | With discount card |
|---|---|---|
| CVS Pharmacy Lowest | $7.90 | $4.90 |
| Kroger Pharmacy | $35.30 | $32.30 |
| Harris Teeter Pharmacy | $35.30 | $32.30 |
| Walgreens | $53.12 | $50.12 |
| Food Lion | $63.89 | — |
| Publix | $68.08 | $65.08 |
| Walmart Neighborhood Market | $69.16 | $66.16 |
| Walmart Pharmacy | $69.16 | $66.16 |
Trimethoprim prices at Canadian pharmacies
| Strength | Pharmacy | Per pill (USD) | Pack total |
|---|---|---|---|
| 200 mg | SPFPharmacy.com | $0.98 | $97.91 / 100 |
| 200 mg | GoldStarMeds.com | $1.06 | $105.71 |
| 200 mg | InhalersOnline.com | $1.15 | $115.38 / 100 |
| 200 mg | 1800RxOnline.com | $1.17 | $117.46 |
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Trimethoprim used for?
Trimethoprim on its own — distinct from the far more commonly prescribed combination sulfamethoxazole-trimethoprim (Bactrim, co-trimoxazole) — is an antifolate antibiotic historically marketed as Proloprim or Trimpex, used alone for uncomplicated urinary tract infections in adults. It blocks a bacterial enzyme in the folic acid synthesis pathway, the same mechanism that gives the sulfa combination its effect, but used alone it lacks the second, complementary mechanism sulfamethoxazole provides, which is one reason the combination product has historically been favored clinically and is far more widely prescribed and studied than standalone trimethoprim.
Because trimethoprim shares its core mechanism with the sulfa combination, many of the same considerations apply even without the sulfonamide component: it can affect folate metabolism, so it's used cautiously in patients at risk for folate deficiency, and it carries interaction potential with drugs metabolized through similar pathways, along with a documented ability to raise potassium levels in some patients, particularly at higher doses or in those with kidney impairment. Unlike the combination product, standalone trimethoprim doesn't carry sulfonamide-specific risks like Stevens-Johnson syndrome or sulfa allergy cross-reactivity, which can make it a reasonable alternative for a patient with a documented sulfa allergy who still needs antifolate-class treatment for a UTI.
Standalone trimethoprim is prescribed far less often today than the combination product, and brand names like Proloprim have become difficult to find, with most current prescribing relying on generic trimethoprim tablets specifically when a prescriber wants antifolate coverage without the sulfa component.
How Trimethoprim works
Blocks bacterial folic acid production
Trimethoprim inhibits an enzyme (dihydrofolate reductase) that bacteria need to make folic acid, which is essential for producing DNA and proteins.
Halts bacterial growth
Without functioning folic acid synthesis, bacteria can't produce the building blocks they need to grow and divide.
The infection clears
With bacterial growth halted, the immune system clears the remaining organisms, typically resolving an uncomplicated UTI within days.
Available forms
tablet
Related & alternative drugs
Commonly used for
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Nausea, vomiting, or diarrhea
- Headache
- Indigestion
Serious — seek care promptly
- Signs of a severe allergic reaction (hives, facial or throat swelling, difficulty breathing)
- Signs of a blood cell count change (unusual bruising, fatigue, fever)
- Elevated potassium levels, especially with kidney impairment
Contraindications
CONTRAINDICATIONS Sulfamethoxazole and trimethoprim tablets are contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency. Sulfamethoxazole and trimethoprim tablets are contraindicated in pediatric patients less than 2 months of age.
Warnings
WARNINGS Embryofetal Toxicity Some epidemiologic studies suggest that exposure to sulfamethoxazole and trimethoprim during pregnancy may be associated with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, and club foot. If sulfamethoxazole and trimethoprim is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be advised of the potential hazards to the fetus.
Known drug interactions
Drug Interactions Potential for Sulfamethoxazole and Trimethoprim to Affect Other Drugs Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter. Sulfamethoxazole is an inhibitor of CYP2C9. Caution is recommended when sulfamethoxazole and trimethoprim is co-administered with drugs that are substrates of CYP2C8 and 2C9 or OCT2. In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. It has been reported that sulfamethoxazole and trimethoprim may prolong the prothrombin time in patients who are receiving the anticoagulant warfarin (a CYP2C9 substrate).
Pregnancy & breastfeeding
Pregnancy While there are no large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell, 10 in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or sulfamethoxazole and trimethoprim. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving sulfamethoxazole and trimethoprim.
Trimethoprim, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Trimethoprim cost without insurance?
Is Trimethoprim cheaper in Canada or the US?
Is there a generic version of Trimethoprim?
What drug class is Trimethoprim in?
Learn more about Trimethoprim
In-depth answers to common Trimethoprim questions, fact-checked against the sources cited in each.
What is Trimethoprim used for?
Trimethoprim is a generic antibiotic prescribed to treat bacterial infections, most commonly urinary tract infections. It is also used to treat certain types of pneumonia and traveler's diarrhea. This medication works by disrupting bacteria's ability to use folic acid, an essential nutrient for their survival and reproduction. Trimethoprim is effective only against bacterial infections; it does not work against viruses or fungi. The dose and length of treatment depend on the type and severity of the infection being treated. Always take this medication exactly as directed by your healthcare provider, and inform them of any existing medical conditions or other medications you are currently taking before beginning treatment.
What are the possible side effects of Trimethoprim?
Common side effects of Trimethoprim include diarrhea, nausea, vomiting, headache, and indigestion. More serious side effects can involve changes in blood cell counts and allergic reactions. Although trimethoprim allergies are relatively uncommon, they can be severe and may present as hives, rash, itching, facial or throat swelling, or trouble breathing. In rare cases, severe allergic reactions can trigger anaphylactic shock—a life-threatening drop in blood pressure that requires immediate emergency care. Seek emergency medical attention right away if you experience signs of an allergic reaction. For a complete list of possible side effects and drug interactions, consult your healthcare provider or pharmacist. Adverse effects can also be reported to the FDA through their MedWatch program.
Page info
Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Aldon Li, M.D., FIDSA, Infectious Disease, Internal Medicine