Xaciato — Compare Prices at US & Canada Pharmacies
Compare real Xaciato prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost for Xaciato without health insurance?
Uninsured patients typically pay around $223.40 for a single 8-gram tube of 2% Xaciato vaginal gel, though prices fluctuate based on pharmacy location and the amount dispensed. Discount programs and pharmacy price-comparison tools can reduce this cost significantly—in some cases to approximately $138.92 for the same quantity. Checking prices across multiple pharmacies may yield additional savings.
What should I expect to pay for Xaciato if I have insurance coverage?
The out-of-pocket cost of Xaciato with insurance depends entirely on your specific plan's formulary, copay structure, and deductible status. Coverage levels and co-pays vary widely across different insurance carriers and plan types. To determine your actual cost, contact your pharmacy or insurance company directly—they can provide details on your plan's coverage and any out-of-pocket expenses you may owe.
Does Medicare provide coverage for Xaciato, and what does it cost?
Many Medicare prescription drug plans include Xaciato in their coverage, though the amount you pay out-of-pocket depends on your specific plan and which tier the medication occupies. To verify coverage, review your plan's formulary or call your plan administrator. Comparing prices through discount pharmacy programs with your Medicare coverage can help identify the lowest available price at your local pharmacy.
Is a generic version of Xaciato available?
Xaciato, manufactured by Organon, remains a brand-name drug with no generic equivalent currently available. Although the active ingredient is clindamycin phosphate in vaginal gel form, no generic substitute has been approved for market release. The brand patent is scheduled to expire in 2036, at which point generic alternatives may become available.
Xaciato prices at US pharmacies
Xaciato — tube, 8gm of 2%, qty 8
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $141.92 | $138.92 |
| Harris Teeter Pharmacy | $141.92 | $138.92 |
| Walgreens | $151.23 | $148.23 |
| Publix | $153.42 | $150.42 |
| Walmart Neighborhood Market | $153.77 | $150.77 |
| Walmart Pharmacy | $153.77 | $150.77 |
| Costco | $154.20 | $151.20 |
| CVS Pharmacy | $166.77 | $163.77 |
Xaciato prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Xaciato in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Xaciato used for?
Xaciato is a single-dose clindamycin vaginal gel for bacterial vaginosis — its entire clinical advantage over older clindamycin vaginal products and oral or vaginal metronidazole is convenience: one prefilled applicator delivers the complete treatment course in a single application, rather than requiring 5–7 days of daily dosing. For patients who struggle to complete multi-day antibiotic courses — historically one of the most common reasons BV treatment fails or recurs — a legitimate one-and-done option removes that adherence problem entirely, similar to how single-dose secnidazole (Solosec) does for the oral route.
Because clindamycin delivered vaginally has very low systemic absorption, Xaciato mostly avoids the concerns associated with oral or IV clindamycin — most notably, it carries far less of the Clostridioides difficile colitis risk that makes systemic clindamycin one of the more cautioned-about antibiotics in that regard, though it isn't zero, and the label still notes CDAD as a rare possible adverse reaction. It's contraindicated in patients with a known hypersensitivity to clindamycin or lincomycin, and — like systemic clindamycin — it retains neuromuscular blocking properties that can theoretically enhance the effect of paralytic agents used in anesthesia, a consideration worth mentioning to any anesthesia team even though absorption from a vaginal gel is minimal.
Xaciato remains brand-only, with its patent not set to expire until 2036, so its price reflects that exclusivity compared with generic metronidazole or clindamycin vaginal cream — a cost that's often the deciding factor between Xaciato and its cheaper, multi-day alternatives when both are clinically reasonable options.
How Xaciato works
Applied directly to the vagina
A single prefilled applicator delivers the full 100 mg clindamycin dose in one intravaginal application.
Blocks bacterial protein synthesis
Clindamycin binds to the bacterial ribosome and stops susceptible bacteria from producing the proteins they need to grow.
Clears the infection
With bacterial growth halted, the vaginal bacterial balance associated with BV can normalize, typically improving symptoms within days.
Available forms
tube
Related & alternative drugs
Commonly used for
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Vaginal itching, irritation, or burning
- Vaginal yeast infection
- Mild redness or swelling at the application site
Serious — seek care promptly
- Signs of a severe allergic reaction
- Severe or persistent diarrhea (possible C. difficile infection, rare with vaginal use)
Contraindications
4 CONTRAINDICATIONS History of hypersensitivity to clindamycin or lincomycin. ( 4.1 ) 4.1 Hypersensitivity XACIATO is contraindicated in individuals with a history of hypersensitivity to clindamycin or lincomycin. [see Adverse Reactions ( 6.2 )] .
Known drug interactions
7 DRUG INTERACTIONS 7.1 Neuromuscular Blocking Agents Systemic clindamycin has neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary Other clindamycin vaginal products have been used to treat pregnant women during the second and third trimester. XACIATO has not been studied in pregnant women. However, based on the low systemic absorption of XACIATO following the intravaginal route of administration in nonpregnant women, maternal use is not likely to result in significant fetal exposure to the drug [see Clinical Pharmacology ( 12.3 )] .
Frequently asked questions
How much does Xaciato cost without insurance?
Is there a generic version of Xaciato?
What drug class is Xaciato in?
Learn more about Xaciato
In-depth answers to common Xaciato questions, fact-checked against the sources cited in each.
What is Xaciato used for?
Xaciato is a prescription vaginal gel designed to treat bacterial vaginosis, a common vaginal infection characterized by an imbalance of natural bacteria. Belonging to the lincosamide class of antibiotics, it works by stopping bacterial growth through inhibition of protein synthesis. Applied directly into the vagina, Xaciato addresses symptoms including abnormal vaginal discharge, odor, and discomfort. The medication is for intravaginal use only.
What dosage options are available for Xaciato?
Xaciato is supplied as a single-dose treatment. Each applicatorful delivers 5 grams of vaginal gel containing 100 milligrams of clindamycin. The prefilled applicator should be discarded after use. Always administer the medication exactly as your healthcare provider has prescribed.
What side effects can occur with Xaciato use?
Most side effects associated with Xaciato are mild and localized. Common reactions include mild itching or irritation, redness, slight swelling, and a burning sensation at the application site. Secondary yeast infections may also develop. Rarely, more serious adverse effects occur, including severe allergic reactions and Clostridium difficile-associated diarrhea. Any severe or persistent symptoms warrant immediate medical evaluation. Discuss potential risks and safety concerns with your healthcare provider before starting treatment.
How long is the treatment course with Xaciato?
Xaciato requires only a single application. One applicatorful (5 grams of vaginal gel containing 100 milligrams of clindamycin) represents the complete course of treatment—no additional doses are needed. Use it according to your healthcare provider's instructions.
Which is more effective for bacterial vaginosis: Xaciato or metronidazole?
Both Xaciato and metronidazole effectively treat bacterial vaginosis, though they differ in administration. Xaciato requires only one intravaginal application, whereas metronidazole is typically taken as an oral tablet or applied topically as a cream or gel over five to seven days. Metronidazole is available in generic formulations, which may affect cost, while Xaciato remains brand-name only. The best choice depends on your infection severity, personal preference regarding dosage form, and healthcare provider recommendation. Discuss your treatment options with your doctor to determine which medication suits your situation.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Angelica Balingit, M.D., Internal Medicine