Zevtera — Compare Prices at US & Canada Pharmacies
Compare real Zevtera prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What should I expect to pay for Zevtera with my insurance?
Insurance coverage for Zevtera depends entirely on your specific plan — some plans cover it, others do not. Your out-of-pocket cost will vary based on your plan's formulary, deductible, copay, and coinsurance terms. Contact your insurance provider directly to confirm whether Zevtera is covered and what your exact cost-sharing responsibility would be. If your plan does not cover this medication, you may want to explore discount pharmacy programs or ask your prescriber about alternative antibiotics that might be more affordable under your coverage.
Zevtera prices at US pharmacies
Zevtera — solution reconstituted, 667mg, qty 4
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $924.32 | $921.32 |
| Harris Teeter Pharmacy | $924.32 | $921.32 |
| Walgreens | $971.19 | $968.19 |
| CVS Pharmacy | $976.80 | $973.80 |
| Publix | $978.08 | $975.08 |
| Walmart Neighborhood Market | $992.51 | $989.51 |
| Walmart Pharmacy | $992.51 | $989.51 |
| Costco | $997.64 | $994.64 |
Zevtera prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Zevtera in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Zevtera used for?
Zevtera (ceftobiprole) is a fifth-generation cephalosporin — the same rare category as ceftaroline (Teflaro) that includes MRSA in its coverage, something older cephalosporins can't touch, since MRSA resistance specifically targets the mechanism most beta-lactams rely on. What sets ceftobiprole apart from ceftaroline is broader Gram-negative coverage, including activity against Pseudomonas aeruginosa — a combination of MRSA-plus-Pseudomonas coverage that few single antibiotics offer. It's approved for S. aureus bloodstream infections (bacteremia), including right-sided infective endocarditis, acute bacterial skin and skin-structure infections, and community-acquired bacterial pneumonia in both adults and children as young as 3 months.
Ceftobiprole had been used in Europe for years before its more recent US approval, so its safety profile is relatively well established internationally even as it's a newer option domestically. Two lab-interference issues are worth knowing: it can cause false-positive results on urine dipstick tests for protein, ketones, or occult blood, so those need confirmation with an alternate method during treatment, and it has the potential to interfere with serological tests like the Coombs test — while clinical trials didn't show hemolytic anemia in adults or children treated with Zevtera, the possibility can't be entirely ruled out, so unexplained anemia during or after treatment is worth investigating with that possibility in mind.
As with other cephalosporins, cross-hypersensitivity with the broader beta-lactam class (including penicillins) is possible, and a history of severe cephalosporin allergy is a contraindication. As a targeted, MRSA-and-Pseudomonas-active reserve antibiotic, Zevtera sits in WHO's Reserve AWaRe category, reserved for infections where this specific combination of coverage is needed rather than used as routine empiric therapy.
How Zevtera works
Blocks bacterial cell wall synthesis
Ceftobiprole binds to penicillin-binding proteins, including PBP2a, the altered protein that lets MRSA resist most other beta-lactams.
Covers MRSA and Pseudomonas
Its ability to bind PBP2a gives it MRSA activity that older cephalosporins lack, while retaining Gram-negative coverage including Pseudomonas aeruginosa.
The bacterial cell dies
Without an intact cell wall, susceptible bacteria — including resistant strains other cephalosporins can't reach — rupture and die.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| S. aureus bacteremia, skin infections, or pneumonia (adults) | 500 mg IV every 8 hours, adjusted for kidney function and infection type | IV infusion (reconstituted) |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Nausea, vomiting, or diarrhea
- Headache
- Injection site reactions
Serious — seek care promptly
- Signs of a severe allergic reaction (rash, swelling, difficulty breathing)
- Severe or persistent diarrhea (possible C. difficile infection)
- Unexplained anemia (possible interference with lab testing or, rarely, hemolytic anemia)
Contraindications
4 CONTRAINDICATIONS ZEVTERA is contraindicated in patients with a known history of severe hypersensitivity to ZEVTERA, or to other members of the cephalosporin class [see Warnings and Precautions (5.2) ]. ZEVTERA is contraindicated in patients with a known history of severe hypersensitivity to ZEVTERA, or to other members of the cephalosporin class ( 4 ).
Known drug interactions
7 DRUG INTERACTIONS 7.1 Drug-Laboratory Test Interactions Dipstick Tests ZEVTERA may result in false-positive results in dipstick tests (urine protein, ketones, or occult blood). Use alternate clinical laboratory methods of testing to confirm positive tests. Serological Testing Treatment with ZEVTERA has the potential to interfere with serological testing, such as the Coombs test. In clinical studies there was no evidence of hemolytic anemia in adults or children. However, the possibility that hemolytic anemia may occur cannot be ruled out. Patients experiencing anemia during or after treatment should be investigated for this possibility.
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary There are no available data with use of ZEVTERA in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes. Available data from published observational studies and case reports over several decades with cephalosporin use in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or other adverse maternal or fetal outcomes .
Zevtera, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Zevtera cost without insurance?
Is there a generic version of Zevtera?
What drug class is Zevtera in?
Learn more about Zevtera
In-depth answers to common Zevtera questions, fact-checked against the sources cited in each.
What are ways to reduce the cost of Zevtera?
Several strategies can help lower what you pay for Zevtera. First, ask your doctor or pharmacist if a generic version is available — generic medications are typically priced significantly lower than brand-name versions. Second, compare prices across different pharmacies in your area, as costs can vary. Third, look into discount prescription programs or manufacturer coupons that may be available to uninsured and underinsured patients. Finally, if you have Medicare or Medicaid, confirm your coverage status with your plan, as eligibility for assistance programs may apply.
Page info
Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Christopher J. Graber, M.D., MPH, FIDSA, Infectious Disease