Aztreonam — Compare Prices at US & Canada Pharmacies
Compare real Aztreonam prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost for Aztreonam without insurance?
The cash price for Aztreonam generally ranges from $164.90 and upward when paid without insurance. Pharmacy discount cards and manufacturer coupons may be available to help lower the final price at the pharmacy counter. Prices can vary between different pharmacy locations, so comparing costs before filling your prescription may help you find the best rate.
What should I expect to pay for Aztreonam if I have health insurance?
Your out-of-pocket cost for Aztreonam depends on your specific insurance plan, deductible status, and whether the drug is on your plan's formulary. Contact your insurance company directly to learn your copay, coinsurance, or deductible obligations. Some patients find that using a pharmacy discount card results in a lower price than their insurance copay, so it may be worth comparing both options.
Is Aztreonam covered by Medicare, and what are the costs?
Aztreonam is covered by most Medicare Part D and Medicare Advantage plans. Your actual out-of-pocket cost will depend on your specific coverage level and whether you have met your deductible for the year. To get an accurate estimate of your costs, contact your Medicare plan administrator or speak with your pharmacist.
What is the brand-name version of Aztreonam?
The brand-name form of aztreonam is Azactam. Aztreonam is manufactured as a generic by Fresenius Kabi USA, LLC.
Aztreonam prices at US pharmacies
(Aztreonam) — solution reconstituted, 1gm, qty 9
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Walgreens Lowest | $124.22 | $121.22 |
| CVS Pharmacy | $128.20 | $125.20 |
| Publix | $205.44 | $202.44 |
| Kroger Pharmacy | $296.15 | $293.15 |
| Harris Teeter Pharmacy | $296.15 | $293.15 |
| Walmart Neighborhood Market | $318.73 | $315.73 |
| Walmart Pharmacy | $318.73 | $315.73 |
Aztreonam prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Aztreonam in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Aztreonam used for?
Aztreonam is the only antibiotic in its class, the monobactams — a structural feature that gives it an unusual advantage: it's active almost exclusively against aerobic gram-negative bacteria (organisms like E. coli, Klebsiella, and Pseudomonas), with essentially no activity against gram-positive bacteria or anaerobes. That narrow spectrum is deliberate, not a limitation — it lets clinicians add gram-negative coverage to a regimen without disturbing the rest of the body's normal bacteria.
Because its molecular structure differs substantially from penicillins, cephalosporins, and carbapenems, aztreonam rarely triggers an allergic reaction in people with a beta-lactam allergy — the FDA label specifically describes it as "rarely cross-reactive" with other beta-lactam antibiotics. That makes it one of the few IV options for a penicillin-allergic patient who needs gram-negative coverage, with one notable exception: people allergic to ceftazidime should still be treated cautiously, since the two drugs share an identical side chain.
The WHO AWaRe framework classifies aztreonam as a Reserve antibiotic. It's given only by injection or IV infusion, for serious infections of the bloodstream, urinary tract, lungs, skin, and abdomen when gram-negative bacteria are confirmed or strongly suspected.
How Aztreonam works
Targets the bacterial cell wall
Like other beta-lactams, aztreonam binds to penicillin-binding proteins that gram-negative bacteria need to build their cell wall.
Wall construction fails
Blocking these proteins prevents the bacterium from properly assembling and repairing its wall as it grows.
The cell breaks apart
Without a functional wall, the bacterium can't withstand internal pressure and ruptures — aztreonam is bactericidal.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| Serious gram-negative infections (adults, normal kidney function) | Typically 1–2 g IV or IM every 6–12 hours, depending on severity | Injection / IV infusion |
| Dosing with reduced kidney function | Dose and interval adjusted based on creatinine clearance | Injection / IV infusion |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Commonly used for
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Diarrhea, nausea, or vomiting
- Injection-site pain, redness, or swelling
- Headache
Serious — seek care promptly
- Signs of an allergic reaction: rash, hives, difficulty breathing
- Severe or watery diarrhea (possible C. diff colitis)
- Yellowing of the skin or eyes, dark urine (possible liver involvement)
Contraindications
CONTRAINDICATIONS This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation.
Warnings
WARNINGS Both animal and human data suggest that aztreonam for injection, USP is rarely cross-reactive with other beta-lactam antibiotics and weakly immunogenic. Treatment with aztreonam can result in hypersensitivity reactions in patients with or without prior exposure. (See CONTRAINDICATIONS . ) Careful inquiry should be made to determine whether the patient has any history of hypersensitivity reactions to any allergens. While cross-reactivity of aztreonam with other beta-lactam antibiotics is rare, this drug should be administered with caution to any patient with a history of hypersensitivity to beta-lactams (e.g., penicillins, cephalosporins, and/or carbapenems).
Pregnancy & breastfeeding
Pregnancy In pregnant women, aztreonam crosses the placenta and enters the fetal circulation. Developmental toxicity studies in pregnant rats and rabbits with daily doses of aztreonam up to 1,800 and 1,200 mg/kg, respectively, revealed no evidence of embryotoxicity or fetotoxicity or teratogenicity. These doses, based on body surface area, are 2.2- and 2.9-fold greater than the MRHD for adults of 8 g per day.
Aztreonam, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Aztreonam cost without insurance?
Is there a generic version of Aztreonam?
What drug class is Aztreonam in?
Learn more about Aztreonam
In-depth answers to common Aztreonam questions, fact-checked against the sources cited in each.
What exactly is Aztreonam and how does it work?
Aztreonam is a generic prescription antibiotic used to treat serious bacterial infections in the blood, urinary tract, respiratory system, skin, abdomen, or female reproductive system. The drug functions by inhibiting bacterial growth. It is administered by injection into a vein or muscle, with dosing determined by your doctor based on your medical history, current medications, and response to treatment. If self-administering at home, follow all preparation and injection instructions provided by your healthcare provider. Before use, visually examine the solution for particles or discoloration and discard if either is present. To maintain effectiveness, use the medication at consistent intervals—ideally at the same time each day to help avoid missed doses. Complete the full course of treatment as prescribed, even if symptoms improve within a few days. Premature discontinuation can allow bacteria to persist and may lead to infection recurrence.
What are the potential side effects of Aztreonam?
Commonly reported side effects include diarrhea, nausea, vomiting, dizziness, headache, blurred vision, and redness or swelling at the injection site. These effects often diminish over time. Contact your doctor or pharmacist if any of these persist or intensify. Most patients tolerate the medication without serious adverse effects. However, seek immediate medical attention if you develop a rapid or irregular heartbeat, confusion, easy bruising or bleeding, ear ringing, seizures, chest pain, yellowing of the skin or eyes, dark-colored urine, severe abdominal pain, persistent nausea or vomiting, or unusual weakness. This list is not exhaustive. Discuss the full range of potential risks and benefits with your healthcare provider before starting treatment.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Aldon Li, M.D., FIDSA, Infectious Disease, Internal Medicine