Neo Synalar (Neo-Synalar) — Compare Prices at US & Canada Pharmacies
Compare real Neo Synalar prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost of Neo-Synalar without health insurance?
The retail price for a 60-gram tube of Neo-Synalar (0.5-0.025%) is approximately $1,212.11. However, uninsured patients may be able to reduce this cost by using pharmacy discount cards or manufacturer coupons, which are often available through various online prescription discount platforms. Actual savings and final pricing depend on which pharmacy discount option you use and which pharmacy fills your prescription.
What will I pay for Neo-Synalar if I have insurance coverage?
Copay amounts for Neo-Synalar vary considerably depending on your specific insurance plan, formulary status, and deductible. To minimize your out-of-pocket expense, compare your insurance copay directly against available pharmacy discount programs. Many patients find that discount cards or manufacturer coupons—which are widely available online—offer better savings than their insurance copay for this particular medication.
Does Medicare provide coverage for Neo-Synalar prescriptions?
Medicare Part D typically does not cover Neo-Synalar, as topical corticosteroid-antibiotic combination products are often excluded from standard drug formularies. Patients without Medicare coverage for this medication can explore pharmacy discount cards, manufacturer coupons, or patient assistance programs directly from the drug manufacturer to reduce their cost at the pharmacy counter.
Is a generic version of Neo-Synalar available?
Neo-Synalar is a branded prescription topical medication that uniquely combines fluocinolone (a corticosteroid) with neomycin (an antibiotic). Although other generic and brand-name products exist that combine a corticosteroid with neomycin, no other formulation currently available pairs fluocinolone specifically with neomycin. If cost is a concern, ask your prescriber whether an alternative combination corticosteroid-antibiotic cream might be suitable for your condition.
Neo Synalar prices at US pharmacies
Neo-Synalar — tube, 60gm of 0.5-0.025%, qty 60
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $949.75 | $946.75 |
| Harris Teeter Pharmacy | $949.75 | $946.75 |
| Food Lion | $993.32 | — |
| Walgreens | $997.87 | $994.87 |
| CVS Pharmacy | $1003.15 | $1000.15 |
| Publix | $1004.91 | $1001.91 |
| Walmart Neighborhood Market | $1019.81 | $1016.81 |
| Walmart Pharmacy | $1019.81 | $1016.81 |
Neo Synalar prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Neo Synalar in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Neo Synalar used for?
Neo-Synalar combines fluocinolone acetonide, a mid-potency topical corticosteroid, with neomycin, an antibiotic, in a single cream for inflamed skin conditions (eczema, dermatitis) that have developed a secondary bacterial infection. Combination steroid-antibiotic products like this exist for convenience — one tube instead of two — but the FDA label itself notes an important limitation: there's no evidence the combination works better than the steroid alone beyond the first week of treatment, which is why these products are generally prescribed for short courses rather than open-ended use once the acute flare and infection are under control.
Neomycin is the more consequential ingredient safety-wise. It's chemically related to other aminoglycosides (gentamicin, tobramycin) and shares their theoretical risk of nephrotoxicity and ototoxicity, though at the tiny doses absorbed from intact skin this risk is low — it becomes more relevant if the cream is applied over large body surface areas, broken or denuded skin, or for prolonged periods, all of which increase systemic absorption. Neomycin is also one of the more common topical allergens in contact dermatitis testing, so a rash that worsens rather than improves on this cream can actually be an allergic reaction to the neomycin itself rather than the infection persisting.
Because it contains a corticosteroid, the same precautions that apply to any topical steroid apply here: prolonged or widespread use can cause skin thinning, stretch marks, or pigment changes at the application site, and enough can be absorbed systemically over large areas or with occlusive dressings to affect the adrenal-pituitary axis in rare cases. It should not be used in the ear if the eardrum is perforated, given the ototoxicity risk from direct middle-ear exposure.
How Neo Synalar works
Reduces inflammation
Fluocinolone, the corticosteroid component, suppresses the local immune and inflammatory response, reducing redness, swelling, and itching.
Targets the bacterial infection
Neomycin, the antibiotic component, disrupts bacterial protein synthesis, killing susceptible bacteria at the application site.
Calms the skin as the infection clears
As inflammation subsides and bacteria are cleared, the skin's barrier can begin to heal — though the combination isn't shown to outperform the steroid alone after about a week.
Available forms
tube
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Burning, stinging, or itching at the application site
- Skin irritation or folliculitis
- Skin thinning or stretch marks with prolonged use
Serious — seek care promptly
- Signs of a severe allergic reaction, including to neomycin itself (worsening rash, hives, swelling)
- Signs of systemic corticosteroid absorption (blurred vision, rapid heartbeat, unusual swelling or weight gain)
- Hearing changes or ringing in the ears with extensive or prolonged use
Contraindications
CONTRAINDICATIONS Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. This product should not be used in the external auditory canal if the eardrum is perforated.
Warnings
WARNINGS If local infection should continue or become severe, or in the presence of systemic infection, appropriate systemic antibacterial therapy, based on susceptibility testing, should be considered. Because of the concern of nephrotoxicity and ototoxicity associated with neomycin, this combination product should not be used over a wide area or for extended periods of time. There are articles in the current medical literature that indicate an increase in the prevalence of persons sensitive to neomycin.
Pregnancy & breastfeeding
Pregnancy Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids.
Frequently asked questions
How much does Neo Synalar cost without insurance?
Is there a generic version of Neo Synalar?
What drug class is Neo Synalar in?
Learn more about Neo Synalar
In-depth answers to common Neo Synalar questions, fact-checked against the sources cited in each.
What is Neo-Synalar and how does it work?
Neo-Synalar is a prescription topical cream used to treat inflammatory skin disorders that have developed a secondary bacterial infection. The medication contains two active ingredients that work synergistically: fluocinolone, a corticosteroid that suppresses inflammation by preventing the body from releasing chemicals that cause swelling and by dampening the immune response to infection, and neomycin, a polypeptide antibiotic that destroys bacteria by disrupting the formation and repair of their cell walls. As bacterial cell walls break down, the organisms lose their contents and die. Fluocinolone also narrows blood vessels in the affected area, decreasing blood flow and further reducing swelling, redness, and associated discomfort. The cream is typically applied as a thin layer to the affected skin two to four times daily, depending on the severity of the condition. Some formulations may be accompanied by a complementary moisturizing product.
What side effects can Neo-Synalar cause?
Side effects of Neo-Synalar are most commonly localized to the skin where the cream is applied and may include stinging, burning, irritation, rash, redness, and folliculitis (small bumps around hair follicles). With prolonged use, skin-related effects can include discoloration, stretch marks, and skin thinning. Because topical corticosteroids can be absorbed through the skin into the bloodstream, systemic side effects are possible and may include blurred vision, dizziness, elevated heart rate, swelling, and weight gain. Extended use can potentially result in kidney damage and hearing loss. Allergic reactions are uncommon but may occur; discontinue use and seek medical attention if you develop a rash, hives, facial or throat swelling, or other signs of an allergic response. This list does not include all possible side effects. If you experience unexpected symptoms or have concerns about side effects, contact your healthcare provider or pharmacist.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Angelica Balingit, M.D., Internal Medicine