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Aminoglycosides WHO AWaRe: Watch Prescription only

Streptomycin — Compare Prices at US & Canada Pharmacies

Compare real Streptomycin prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.

Drug class
Aminoglycosides
Common forms
Injectable (reconstituted)
Generic available
Yes
Legal status
Prescription only

What is the typical out-of-pocket cost for Streptomycin Sulfate?

Without insurance coverage, Streptomycin Sulfate typically costs around $961.34 per 10, 1gm solution reconstituteds at retail pharmacy prices. Patients may be able to reduce this cost by using prescription discount cards or coupons available through various pharmacy discount programs. Choosing the generic form of Streptomycin Sulfate rather than the branded version Ambistryn-S can result in meaningful savings on your medication expenses.

How does insurance affect the price of Streptomycin Sulfate?

Insurance coverage for Streptomycin Sulfate depends entirely on your individual plan's formulary and benefit structure. Each insurance provider has different rules about which medications they cover and what your out-of-pocket responsibility will be. To find out whether your plan covers Streptomycin Sulfate and what your copay or coinsurance would be, contact your insurance company directly. If your plan does not cover this medication, you may have options to reduce the cost through pharmacy discount programs.

What brand-name alternative exists for Streptomycin Sulfate?

Ambistryn-S is the brand-name formulation of Streptomycin Sulfate. The generic version and the branded version contain the same active ingredient but differ significantly in price, with the generic form costing considerably less. Many patients and healthcare providers opt for the generic Streptomycin Sulfate to achieve the same therapeutic benefit at a lower out-of-pocket cost.

Streptomycin prices at US pharmacies

Streptomycin Sulfate — solution reconstituted, 1gm, qty 10

PharmacyRetail priceWith discount card
Kroger Pharmacy Lowest $387.03 $384.03
Harris Teeter Pharmacy $387.03 $384.03
CVS Pharmacy $404.29 $401.29
Walgreens $407.53 $404.53
Publix $411.12 $408.12
Walmart Neighborhood Market $415.67 $412.67
Walmart Pharmacy $415.67 $412.67

Streptomycin prices at Canadian pharmacies

No Canadian pharmacy pricing was found for Streptomycin in our latest data pull.

Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.

What is Streptomycin used for?

Streptomycin Sulfate is an aminoglycoside antibiotic produced by Xgen Pharmaceuticals Djb. The average retail price for this medication is $961.34 per 10, 1gm solution reconstituteds. Streptomycin Sulfate is available as a generic medication; Ambistryn-S is the brand-name equivalent.

Available forms

solution reconstituted

Related & alternative drugs

Warnings & interactions

This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.

Boxed warning

WARNING THE RISK OF SEVERE NEUROTOXIC REACTIONS IS SHARPLY INCREASED IN PATIENTS WITH IMPAIRED RENAL FUNCTION OR PRE-RENAL AZOTEMIA. THESE INCLUDE DISTURBANCES OF VESTIBULAR AND COCHLEAR FUNCTION, OPTIC NERVE DYSFUNCTION, PERIPHERAL NEURITIS, ARACHNOIDITIS, AND ENCEPHALOPATHY MAY ALSO OCCUR. THE INCIDENCE OF CLINICALLY DETECTABLE, IRREVERSIBLE VESTIBULAR DAMAGE IS PARTICULARLY HIGH IN PATIENTS TREATED WITH STREPTOMYCIN. RENAL FUNCTION SHOULD BE MONITORED CAREFULLY; PATIENTS WITH RENAL IMPAIRMENT AND/OR NITROGEN RETENTION SHOULD RECEIVE REDUCED DOSES. THE PEAK SERUM CONCENTRATION IN INDIVIDUALS WITH KIDNEY DAMAGE SHOULD NOT EXCEED 20 TO 25 MCG/ML.

Contraindications

CONTRAINDICATIONS A history of clinically significant hypersensitivity to streptomycin is a contraindication to its use. Clinically significant hypersensitivity to other aminoglycosides may contraindicate the use of streptomycin because of the known cross-sensitivity of patients to drugs in this class.

Warnings

WARNINGS Ototoxicity Both vestibular and auditory dysfunction can follow the administration of streptomycin. The degree of impairment is directly proportional to the dose and duration of streptomycin administration, to the age of the patient, to the level of renal function and to the amount of underlying existing auditory dysfunction. The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the co-administration of ethacrynic acid, mannitol, furosemide and possibly other diuretics. The vestibulotoxic potential of streptomycin exceeds that of its capacity for cochlear toxicity. Vestibular damage is heralded by headache, nausea, vomiting and disequilibrium.

Known drug interactions

Drug Interactions The ototoxic effects of the aminoglycosides, including streptomycin, are potentiated by the coadministration of ethacrynic acid, furosemide, mannitol and possibly other diuretics.

Pregnancy & breastfeeding

Pregnancy See WARNINGS section.

Streptomycin, by the numbers

Additional public data points beyond retail pricing — useful context, not a price quote.

$2.1M
Medicare Part D spend, 2024
1.1K
Medicare Part D claims, 2024
4
FDA-listed manufacturers (Orange Book)
$351.76
Federal (VA) contract price per pack (10)

Frequently asked questions

How much does Streptomycin cost without insurance?
Retail (no-insurance) prices we found for Streptomycin range up to about $415.67 depending on pharmacy, form, and quantity. With a free pharmacy discount card, the lowest price we found was $384.03. Your actual price depends on the exact strength, quantity, and pharmacy — see the tables above.
Is there a generic version of Streptomycin?
Yes — our pricing data includes at least one generic listing for Streptomycin. Generics contain the same active ingredient and are typically the lowest-cost option; check the price tables above for the generic rows specifically.
What drug class is Streptomycin in?
Streptomycin belongs to the aminoglycosides class of antibiotics. WHO classifies it as an 'Watch' antibiotic under its AWaRe stewardship framework.

Sources

Page info

Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.