Xepi — Compare Prices at US & Canada Pharmacies
Compare real Xepi prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical cost of Xepi without insurance coverage?
Xepi cream generally costs around $1,473.99 without insurance. However, several strategies can lower this price. Prescription discount coupons or savings cards may reduce the cost to approximately $1,224.50 per 10-gram tube, depending on the pharmacy. Comparing prices across different retailers such as Kroger, Walgreens, CVS, Target, and Walmart can reveal additional savings opportunities.
What should I expect to pay for Xepi if I have insurance?
Insurance coverage for Xepi varies significantly by plan type and individual policy terms. Your out-of-pocket expense depends on your deductible, copay structure, and coinsurance percentage. Pharmacists can help calculate your expected copay at the time of fill. Comparing prices across local pharmacies before filling your prescription may identify lower costs than your standard insurance copay.
Does Medicare provide coverage for Xepi, and what would I pay?
Medicare does not currently cover Xepi. Beneficiaries paying out-of-pocket can use discount prescription cards to reduce costs. Discount cards typically bring the price down to around $1,224.50 per tube. Checking multiple pharmacies for their cash prices remains a practical way to find the most affordable option.
Is a generic version of Xepi available?
No generic version of Xepi currently exists. Xepi is a brand-name prescription medication manufactured by Dermarc, LLC, a subsidiary of Cutanea Life Sciences, Inc.
Xepi prices at US pharmacies
Xepi — tube, 10gm of 1%, qty 10
| Pharmacy | Retail price | With discount card |
|---|---|---|
| Kroger Pharmacy Lowest | $1227.50 | $1224.50 |
| Harris Teeter Pharmacy | $1227.50 | $1224.50 |
| Food Lion | $1283.00 | — |
| Walgreens | $1289.25 | $1286.25 |
| CVS Pharmacy | $1290.92 | $1287.92 |
| Publix | $1298.00 | $1295.00 |
| Walmart Neighborhood Market | $1318.01 | $1315.01 |
| Walmart Pharmacy | $1318.01 | $1315.01 |
Xepi prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Xepi in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Xepi used for?
Xepi (ozenoxacin) is a topical quinolone — the same broad drug family as oral fluoroquinolones like ciprofloxacin, but formulated exclusively for the skin and approved narrowly for impetigo caused by Staphylococcus aureus or Streptococcus pyogenes in patients as young as 2 months. That narrow approval matters: because systemic absorption from the cream is negligible even at twice the marketed concentration, Xepi doesn't carry the tendon rupture, peripheral neuropathy, or CNS effects that define the boxed warnings on oral and IV fluoroquinolones — a point worth being clear about, since the "quinolone" family name alone tends to raise those associations for patients or caregivers who've heard about fluoroquinolone safety concerns in other contexts.
As a newer quinolone class member developed with resistant Gram-positive skin bacteria specifically in mind, ozenoxacin offers an alternative to mupirocin for treating impetigo — a distinction that matters as mupirocin resistance in S. aureus has become increasingly common after decades of widespread use. Impetigo is highly contagious, especially among young children in close contact settings like daycare, and treating it promptly with an effective topical antibiotic helps limit spread as well as clear the individual infection.
Xepi remains brand-only with a notably high price point compared with mupirocin or other topical antibiotics, which is one practical reason mupirocin often remains the first choice despite rising resistance, with Xepi reserved for cases where mupirocin isn't effective or appropriate. As with other topical antibiotics, the full prescribed course should be completed even if the skin looks better within a few days, and a lack of improvement within 3 days should prompt a follow-up rather than continued self-treatment.
Available forms
tube
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Redness, itching, or dryness at the application site
- Skin peeling or flaking
Serious — seek care promptly
- Signs of a severe allergic reaction (hives, widespread rash, facial or throat swelling, difficulty breathing)
- Signs of a new or worsening skin infection
Contraindications
4 CONTRAINDICATIONS None. None ( 4 )
Pregnancy & breastfeeding
8.1 Pregnancy Risk Summary There are no available data on the use of XEPI in pregnant women to inform a drug associated risk. Systemic absorption of XEPI in humans is negligible following topical administration of XEPI (up to twice the concentration of the marketed formulation) [see Clinical Pharmacology (12.3) ] . Due to the negligible systemic exposure, it is not expected that maternal use of XEPI will result in fetal exposure to the drug.
Frequently asked questions
How much does Xepi cost without insurance?
Is there a generic version of Xepi?
What drug class is Xepi in?
Learn more about Xepi
In-depth answers to common Xepi questions, fact-checked against the sources cited in each.
What is Xepi and how does it work?
Xepi is a quinolone antibiotic cream designed to treat impetigo, commonly called school sores—a highly contagious skin infection primarily affecting infants and young children. The active ingredient, ozenoxacin, works by stopping bacterial growth and preventing the infection from spreading. The medication is approved for use in patients aged two months and older. Xepi is applied topically as a thin layer over affected skin and is never taken by mouth. After application, wash your hands unless treating an area on your hands, then optionally cover the site with gauze or a bandage. Continue using Xepi for your full prescribed course even if symptoms improve, as stopping early increases the risk of incomplete treatment and recurrence. Consult your doctor if no improvement occurs within three days. Before starting Xepi, inform your doctor of any allergies to ozenoxacin or other ingredients, existing medical conditions, pregnancy or breastfeeding status, and all current medications (prescription, over-the-counter, and supplements).
What side effects might occur with Xepi use?
The most commonly reported side effects of Xepi include localized skin reactions at the application site: redness, itching, dryness, peeling, or flaking. Seek immediate medical care if you develop signs of a new skin infection or experience allergic reaction symptoms such as hives, widespread rash, severe itching, difficulty breathing, or swelling of the face, lips, throat, or tongue. This list does not capture all possible adverse effects. Your healthcare provider can discuss the full range of potential risks and benefits specific to your situation. Any side effects can also be reported directly to the FDA.
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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Angelica Balingit, M.D., Internal Medicine