Clindamycin Tretinoin (Ziana) — Compare Prices at US & Canada Pharmacies
Compare real Clindamycin Tretinoin prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.
What is the typical out-of-pocket cost for Clindamycin-Tretinoin without insurance?
Without insurance coverage, Clindamycin-Tretinoin typically costs around $455.27 per 30gm tube of 1.2-0.025% gel at retail pharmacies. However, prices vary by pharmacy and location. Uninsured patients may qualify for manufacturer coupons or pharmacy discount programs that can reduce the cost significantly. Comparing prices across multiple pharmacies before filling your prescription can help you find the lowest available rate.
Will insurance cover Clindamycin-Tretinoin, and what might I pay?
Insurance coverage and out-of-pocket costs for Clindamycin-Tretinoin depend entirely on your individual plan. Some plans cover this medication fully or partially; others may not include it at all. Contact your insurance provider directly to confirm whether Clindamycin-Tretinoin is on your formulary and what your copay or coinsurance would be. If your insurer does not cover the medication or your copay is high, you may want to compare that cost against pharmacy discount programs or manufacturer coupons, which sometimes offer lower prices than your insurance coinsurance.
How does the generic Clindamycin-Tretinoin compare in price to the brand-name Veltin?
Clindamycin-Tretinoin is the generic version of Veltin and is substantially less expensive. Both contain the same active ingredients and work identically, but the generic formulation typically costs far less because manufacturers do not bear the research and marketing expenses associated with brand-name drugs. If cost is a concern, asking your healthcare provider or pharmacist about the generic option can lead to meaningful savings on this acne treatment.
Clindamycin Tretinoin prices at US pharmacies
(Clindamycin-Tretinoin) — tube of gel, 30gm of 1.2-0.025%, qty 30
| Pharmacy | Retail price | With discount card |
|---|---|---|
| CVS Pharmacy Lowest | $98.54 | $95.54 |
| Food Lion | $166.40 | — |
| Walgreens | $169.42 | $166.42 |
| Walmart Neighborhood Market | $176.75 | $173.75 |
| Walmart Pharmacy | $176.75 | $173.75 |
| Kroger Pharmacy | $181.23 | $178.23 |
| Harris Teeter Pharmacy | $181.23 | $178.23 |
| Publix | $208.50 | $205.50 |
Ziana (Clindamycin-Tretinoin) — tube of gel, 30gm of 1.2-0.025%, qty 30
| Pharmacy | Retail price | With discount card |
|---|---|---|
| CVS Pharmacy Lowest | $98.54 | $95.54 |
| Food Lion | $166.40 | — |
| Walgreens | $169.42 | $166.42 |
| Walmart Neighborhood Market | $176.75 | $173.75 |
| Walmart Pharmacy | $176.75 | $173.75 |
| Kroger Pharmacy | $181.23 | $178.23 |
| Harris Teeter Pharmacy | $181.23 | $178.23 |
| Publix | $208.50 | $205.50 |
Clindamycin Tretinoin prices at Canadian pharmacies
No Canadian pharmacy pricing was found for Clindamycin Tretinoin in our latest data pull.
Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.
What is Clindamycin Tretinoin used for?
Clindamycin-tretinoin combines a topical antibiotic with a retinoid in a single gel, sold under brand names including Ziana and Veltin, for treating acne in patients 12 and older. Clindamycin reduces acne-causing bacteria and inflammation, while tretinoin — a vitamin A derivative — speeds up skin cell turnover, helping unclog pores and prevent the buildup that leads to new blemishes. This dual action targets both the bacterial and the follicular (pore-clogging) sides of acne in one product.
Because tretinoin is a retinoid, expect an adjustment period: dryness, peeling, redness, and increased sun sensitivity are common in the first few weeks as skin adapts, and daily sunscreen use is important throughout treatment. As with any clindamycin-containing product, the FDA label notes a caution about colitis linked to C. diff, and it isn't recommended for people with a history of ulcerative colitis, Crohn's disease, or prior antibiotic-associated colitis.
Tretinoin also makes skin more prone to irritation from other acne products, so combining this gel with additional benzoyl peroxide or harsh exfoliants at the same time can be counterproductive — most dermatologists recommend applying it as a stand-alone step in a simple routine, at least until skin adjusts.
How Clindamycin Tretinoin works
Clindamycin reduces bacteria and inflammation
It suppresses growth of Cutibacterium acnes and calms the inflammatory response driving acne lesions.
Tretinoin speeds up skin cell turnover
It helps shed dead skin cells faster, preventing them from clogging pores and forming new comedones.
Pores stay clearer and breakouts decrease
Together, the two address both new lesion formation and existing inflammation over weeks of consistent use.
Typical dosage forms & strengths
| Use | Typical adult dose | Form |
|---|---|---|
| Acne vulgaris (ages 12+) | Apply a thin layer to affected areas once daily at bedtime | Topical gel (1.2%/0.025%) |
General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.
Related & alternative drugs
Warnings & interactions
This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.
Common, usually mild
- Dryness, peeling, redness
- Increased sun sensitivity
- Mild stinging or burning when starting treatment
Serious — seek care promptly
- Severe, persistent, or bloody diarrhea (rare, possible C. diff colitis)
- Signs of an allergic reaction: rash, hives, swelling, trouble breathing
Contraindications
4 CONTRAINDICATIONS Clindamycin phosphate and tretinoin gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis. Clindamycin phosphate and tretinoin gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic- associated colitis. (4)
Notable drug interactions
| Drug / substance | What can happen |
|---|---|
| Topical or oral erythromycin | Can antagonize the clindamycin component; avoid combining. |
| Other topical acne treatments (benzoyl peroxide, exfoliants) | Can increase skin irritation when combined with a retinoid; introduce gradually. |
Pregnancy & breastfeeding
8.1 Pregnancy Pregnancy Category C. There are no well-controlled studies in pregnant women treated with clindamycin phosphate and tretinoin gel. Clindamycin phosphate and tretinoin gel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Clindamycin Tretinoin, by the numbers
Additional public data points beyond retail pricing — useful context, not a price quote.
Frequently asked questions
How much does Clindamycin Tretinoin cost without insurance?
Is there a generic version of Clindamycin Tretinoin?
Is Clindamycin Tretinoin currently in shortage?
What drug class is Clindamycin Tretinoin in?
Page info
Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.
Angelica Balingit, M.D., Internal Medicine