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Cephalosporins - 2nd Generation WHO AWaRe: Watch Prescription only

Cefaclor — Compare Prices at US & Canada Pharmacies

Compare real Cefaclor prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives. Save up to 6% by comparing Canada pharmacy prices.

Drug class
Cephalosporins - 2nd Generation
AWaRe category
Watch
Common forms
Capsule, Extended-release tablet
Penicillin cross-reactivity
Documented in up to ~10%
Generic available
Yes
Legal status
Prescription only

What is the typical cost of cefaclor without insurance coverage?

The standard retail price for cefaclor is approximately $132.62 for a 30-day supply of 500 mg capsules. Many uninsured patients can reduce this cost by using prescription discount programs or comparing prices across different pharmacies, which may lower the final out-of-pocket amount significantly.

How much will cefaclor cost if I have insurance?

Your out-of-pocket cost depends on your specific insurance plan's copay or coinsurance structure. Many plans cover cefaclor, but copay amounts vary widely. It's worth comparing your insurance copay with the cash price and any available pharmacy discounts—sometimes the lowest price comes from a combination of options rather than insurance alone.

Is cefaclor covered by Medicare, and what would I pay?

Cefaclor is typically covered under Medicare Advantage and Medicare Part D prescription drug plans for eligible beneficiaries. Your actual cost will depend on your specific plan's formulary status, deductible, and coverage tier. Patients can also explore pharmacy discount programs to compare pricing options.

What is the brand name for cefaclor?

Cefaclor is the generic name for the antibiotic originally branded as Ceclor, manufactured by Eli Lilly. Multiple generic manufacturers produce cefaclor, including Apotex and Ranbaxy, among others. Generic versions are bioequivalent to the brand-name product and typically cost less.

🇺🇸 United States
Lowest found, per pill
$3.12
Oral tablet/capsule, discount-card price
🇨🇦 Canada
Lowest found, per pill
$2.93
Oral tablet/capsule, USD equivalent
Canada is typically cheaper for Cefaclor Save up to 6%

"As low as" figures compare the single lowest oral tablet/capsule price found on each side — not necessarily the same strength or pack size. Always check the full tables below for your exact dose. Prices updated 2026-08-21.

Cefaclor prices at US pharmacies

Cefaclor — capsule, 500mg, qty 30

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $96.75 $93.75
Kroger Pharmacy $128.79 $125.79
Harris Teeter Pharmacy $128.79 $125.79
Walgreens $136.62 $133.62
Walmart Neighborhood Market $138.41 $135.41
Walmart Pharmacy $138.41 $135.41
Publix $138.63 $135.63
Food Lion $137.11 —

Cefaclor Er — tablet extended release 12 hour, 500mg, qty 14

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $222.83 $219.83
Kroger Pharmacy $271.13 $268.13
Harris Teeter Pharmacy $271.13 $268.13
Walgreens $285.94 $282.94
Food Lion $285.56 —
Publix $288.83 $285.83
Walmart Neighborhood Market $291.23 $288.23
Walmart Pharmacy $291.23 $288.23

Cefaclor prices at Canadian pharmacies

StrengthPharmacyPer pill (USD)Pack total
Default InhalersOnline.com $2.93 $246.42 / 84
Default InhalersOnline.com $3.95 $55.33 / 14
StrengthPharmacyPer pill (USD)Pack total
Default InhalersOnline.com $2.93 $246.42 / 84
Default InhalersOnline.com $3.95 $55.33 / 14
StrengthPharmacyPer pill (USD)Pack total
Default InhalersOnline.com $2.93 $246.42 / 84
Default InhalersOnline.com $3.95 $55.33 / 14

Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.

What is Cefaclor used for?

Cefaclor is a second-generation cephalosporin antibiotic, structurally related to penicillins, used for common bacterial infections such as middle ear infections, sinusitis, tonsillitis, bronchitis, urinary tract infections, and skin infections. It comes as both an immediate-release capsule/oral suspension and an extended-release tablet — though the FDA label notes the extended-release form hasn't been established as effective for all the same infections the standard formulation treats, so the two aren't automatically interchangeable.

Like other cephalosporins, cefaclor shares a chemical backbone with penicillins, and cross-reactivity is documented in up to about 10% of people with a penicillin allergy — worth discussing with your prescriber if you have a known penicillin allergy, even though outright avoidance isn't always necessary. The WHO AWaRe framework classifies cefaclor as a Watch antibiotic, a category for drugs with a higher potential to contribute to antibiotic resistance if overused, reflecting that second-generation cephalosporins are a step up in spectrum from first-line options like amoxicillin.

Cefaclor is taken multiple times a day for the standard capsule form (spacing antacids apart, since they can reduce absorption), while the extended-release tablet is dosed twice daily and must be swallowed whole rather than crushed or chewed.

How Cefaclor works

  1. Attacks the bacterial cell wall

    Like penicillins, cefaclor blocks the enzymes bacteria need to build and maintain their protective cell wall.

  2. The wall weakens and fails

    Without a properly built wall, internal pressure causes the bacterial cell to rupture.

  3. Susceptible bacteria clear

    As bacterial numbers drop, the immune system finishes clearing the infection.

Typical dosage forms & strengths

UseTypical adult doseForm
Most common infections (adults, immediate-release)250–500 mg every 8 hoursCapsule / oral suspension
Most common infections (extended-release)500 mg every 12 hours, swallowed wholeExtended-release tablet

General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.

Related & alternative drugs

Commonly used for

Warnings & interactions

This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.

Common, usually mild

  • Diarrhea, nausea, or stomach upset
  • Headache
  • Mild skin rash

Serious — seek care promptly

  • Signs of an allergic reaction: hives, facial/throat swelling, trouble breathing
  • Severe or watery diarrhea (possible C. diff colitis)
  • Easy bruising or unusual bleeding (rare interaction with warfarin)

Contraindications

CONTRAINDICATIONS Cefaclor extended-release tablets are contraindicated in patients with known hypersensitivity to cefaclor and other cephalosporins.

Warnings

WARNINGS BEFORE THERAPY WITH CEFACLOR EXTENDED-RELEASE TABLETS IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFACLOR, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. IF THIS PRODUCT IS TO BE GIVEN TO PENICILLIN-SENSITIVE PATIENTS, CAUTION SHOULD BE EXERCISED BECAUSE CROSS-SENSITIVITY AMONG BETA-LACTAM ANTIBIOTICS HAS BEEN CLEARLY DOCUMENTED AND MAY OCCUR IN UP TO 10% OF PATIENTS WITH A HISTORY OF PENICILLIN ALLERGY. IF AN ALLERGIC REACTION TO CEFACLOR EXTENDED-RELEASE TABLETS OCCURS, DISCONTINUE THE DRUG.

Notable drug interactions

Drug / substanceWhat can happen
Antacids (magnesium/aluminum hydroxide)Reduce absorption of the extended-release tablet if taken within an hour — space doses apart.
ProbenecidSlows renal clearance of cefaclor, raising blood levels.
WarfarinRare reports of increased bleeding risk when combined; monitoring may be advised.

Pregnancy & breastfeeding

Usage in Pregnancy Teratogenic Effect Reproduction studies using cefaclor have been performed in mice, rats and ferrets at doses up to 3 to 5 times the maximum human dose (1500 mg/day) based on mg/m 2 . These studies have revealed no harm to the fetus due to cefaclor. There are, however, no adequate and well-controlled studies in pregnant women.

Cefaclor, by the numbers

Additional public data points beyond retail pricing — useful context, not a price quote.

$0.6M
Medicare Part D spend, 2024
9.5K
Medicare Part D claims, 2024
13
FDA-listed manufacturers (Orange Book)

Frequently asked questions

How much does Cefaclor cost without insurance?
Retail (no-insurance) prices we found for Cefaclor range up to about $291.23 depending on pharmacy, form, and quantity. With a free pharmacy discount card, the lowest price we found was $93.75. Your actual price depends on the exact strength, quantity, and pharmacy — see the tables above.
Is Cefaclor cheaper in Canada or the US?
Based on the oral tablet/capsule prices in our data, Canada was cheaper for Cefaclor — as low as $3.12/pill in the US versus $2.93/pill in Canada, a difference of about 6%. This compares the single lowest price found on each side, not necessarily the same exact strength.
Is there a generic version of Cefaclor?
Yes — our pricing data includes at least one generic listing for Cefaclor. Generics contain the same active ingredient and are typically the lowest-cost option; check the price tables above for the generic rows specifically.
What drug class is Cefaclor in?
Cefaclor belongs to the cephalosporins - 2nd generation class of antibiotics. WHO classifies it as an 'Watch' antibiotic under its AWaRe stewardship framework.

Learn more about Cefaclor

In-depth answers to common Cefaclor questions, fact-checked against the sources cited in each.

What exactly is cefaclor and how does it work?

Cefaclor is a generic antibiotic belonging to the cephalosporin class of drugs, which are structurally related to penicillins. It eliminates bacteria by disrupting their ability to synthesize and maintain a rigid cell wall. Once the cell wall is compromised, bacteria cannot retain their internal contents and die. The drug is available as a tablet or oral suspension and is prescribed for bacterial infections such as middle ear infections, pneumonia, strep throat, tonsillitis, urinary tract infections, and skin infections caused by staph or strep organisms. Dosage and duration depend on the infection type and severity. Cefaclor works only against bacteria and has no effect on viral infections.

What side effects might occur with cefaclor?

Most people tolerate cefaclor well, though some experience side effects. Gastrointestinal symptoms are the most frequently reported, including stomach upset, diarrhea, nausea, and headache. Allergic reactions to cefaclor are relatively common and may present as rash, itching, or swelling. In rare cases, severe allergic reactions such as anaphylaxis—characterized by a dangerous drop in blood pressure—can occur and require immediate medical attention. Anyone experiencing signs of an allergic reaction should seek emergency care. This is not an exhaustive list of possible side effects; discuss potential adverse effects with your healthcare provider or pharmacist before starting this medication.


Sources

Page info

Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.