Cefoxitin Dextrose — Compare Prices at US & Canada Pharmacies

Cefoxitin-dextrose is the same second-generation cephamycin antibiotic as standard cefoxitin, supplied premixed in a ready-to-infuse dextrose IV solution rather than a powder that needs reconstitution — the FDA label for this premixed formulation specifies it's for intravenous use only. That's a formulation convenience common in hospitals, since a premixed bag saves preparation time and reduces the chance of a dosing error; the drug itself, its uses, and its precautions are the same as plain cefoxitin.

Like standard cefoxitin, it's used for serious respiratory, urinary tract, and intra-abdominal or pelvic infections, and as a standard choice for preventing infection before abdominal or gynecologic surgery, thanks to its useful anaerobic bacterial coverage compared with other second-generation cephalosporins.

As a dextrose-containing solution, this formulation may not be appropriate for patients with a known corn allergy, since dextrose is typically corn-derived — otherwise it's handled the same way as cefoxitin supplied as a powder for reconstitution.

Contraindications

CONTRAINDICATIONS MEFOXIN is contraindicated in patients who have shown hypersensitivity to cefoxitin and the cephalosporin group of antibiotics.

Warnings

WARNINGS BEFORE THERAPY WITH 'MEFOXIN' IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFOXITIN, CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. THIS PRODUCT SHOULD BE GIVEN WITH CAUTION TO PENICILLIN-SENSITIVE PATIENTS. ANTIBIOTICS SHOULD BE ADMINISTERED WITH CAUTION TO ANY PATIENT WHO HAS DEMONSTRATED SOME FORM OF ALLERGY, PARTICULARLY TO DRUGS. IF AN ALLERGIC REACTION TO 'MEFOXIN' OCCURS, DISCONTINUE THE DRUG. SERIOUS HYPERSENSITIVITY REACTIONS MAY REQUIRE EPINEPHRINE AND OTHER EMERGENCY MEASURES.

Known drug interactions

Drug Interactions Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.

Pregnancy & breastfeeding

Pregnancy Pregnancy Category B Reproduction studies performed in rats and mice at parenteral doses of approximately one to seven and one-half times the maximum recommended human dose did not reveal teratogenic or fetal toxic effects, although a slight decrease in fetal weight was observed. There are, however, no adequate and well-controlled studies in pregnant women.