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Cephalosporins - 2nd Generation WHO AWaRe: Watch Prescription only

Cefuroxime Axetil — Compare Prices at US & Canada Pharmacies

Compare real Cefuroxime Axetil prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives.

Generic name Cefuroxime Axetil
US brand names
Ceftin
Also sold as
Zinacef (IV form)Apo-Cefuroxime (Canada)
Drug class
2nd-generation cephalosporin
Typical course
5–10 daysvaries by infection
Common forms
Tablet, oral suspension
Generic available
Yeslow cost

How much does Ceftin cost without insurance?

Generic cefuroxime axetil is typically inexpensive with a discount card. See the pharmacy-by-pharmacy pricing above for real current numbers for your strength and quantity.

Is there a generic version of Ceftin?

Yes — generic cefuroxime axetil is what's dispensed by default at most pharmacies.

Do I need a prescription for Ceftin?

Yes, in the US and Canada. It's not available over the counter.

How can I save on cefuroxime?

Compare discount-card pricing across pharmacies for the exact strength and quantity prescribed — the spread can be meaningful even for a well-established generic.

Cefuroxime Axetil prices at US pharmacies

(Cefuroxime Axetil) — tablet, 500mg, qty 14

PharmacyRetail priceWith discount card
Kroger Pharmacy Lowest $17.70 $14.70
Harris Teeter Pharmacy $17.70 $14.70
Food Lion $15.91
Walmart Neighborhood Market $19.62 $16.62
Walmart Pharmacy $19.62 $16.62
Walgreens $20.25 $17.25
Publix $23.29
CVS Pharmacy $27.21 $24.21

Cefuroxime Axetil prices at Canadian pharmacies

No Canadian pharmacy pricing was found for Cefuroxime Axetil in our latest data pull.

Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.

What is Cefuroxime Axetil used for?

Cefuroxime axetil is a second-generation cephalosporin — a step up in bacterial coverage from first-generation cephalosporins like cephalexin, while still being taken by mouth rather than requiring an IV. It's commonly used for sinus infections, some ear infections, certain respiratory infections, and early Lyme disease as an alternative to doxycycline (particularly during pregnancy, when doxycycline is generally avoided).

One practical note that trips people up: it needs to be taken with food specifically, because food meaningfully increases how much of the drug your body actually absorbs — taking it on an empty stomach can mean getting less of the intended dose.

It's related to (but distinct from) penicillin-class antibiotics; people with a penicillin allergy have a small but real chance of also reacting to cephalosporins, which is worth discussing with your prescriber if your allergy history includes a serious reaction.

How Cefuroxime Axetil works

  1. Targets the bacterial cell wall

    Like penicillins, cefuroxime is a beta-lactam antibiotic that blocks the construction of the bacterial cell wall.

  2. Resists some bacterial defenses

    It's more stable against certain beta-lactamase enzymes than first-generation cephalosporins or plain penicillins, extending its reach to some bacteria that have developed resistance to older drugs.

  3. The bacterial cell ruptures

    Without an intact wall, the bacterial cell can't withstand internal pressure and breaks apart — a direct, bactericidal effect.

Typical dosage forms & strengths

UseTypical adult doseForm
Most common infections (adults)250–500 mg every 12 hours, with foodTablet
Early Lyme disease500 mg every 12 hours for 20 daysTablet
ChildrenWeight-based, divided into 2 dosesOral suspension

General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.

Related & alternative drugs

Warnings & interactions

This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.

Common, usually mild

  • Diarrhea
  • Nausea
  • Headache
  • Mild rash

Serious — seek care promptly

  • Severe or watery diarrhea (possible C. diff)
  • Signs of an allergic reaction: hives, facial/throat swelling, trouble breathing
  • Severe skin reaction (blistering, peeling)
  • Unusual bruising or bleeding

Contraindications

4 CONTRAINDICATIONS Cefuroxime axetil tablets are contraindicated in patients with a known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil tablets or to other β-lactam antibacterial drugs (e.g., penicillins and cephalosporins). Known hypersensitivity (e.g., anaphylaxis) to cefuroxime axetil tablets or to other β-lactams (e.g., penicillins and cephalosporins). ( 4 )

Notable drug interactions

Drug / substanceWhat can happen
Antacids or acid reducers (H2 blockers, PPIs)Can reduce cefuroxime absorption — timing matters more with this drug than with many antibiotics.
ProbenecidSlows elimination, raising and prolonging blood levels.
Oral contraceptivesRarely reported to reduce effectiveness; a backup method is a reasonable precaution.
WarfarinMay enhance anticoagulant effect in some people; monitoring is a reasonable precaution.

Pregnancy & breastfeeding

8.1 Pregnancy Risk Summary Available data from published epidemiologic studies, case series, and case reports over several decades with cephalosporin use, including cefuroxime axetil, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) .

Cefuroxime Axetil, by the numbers

Additional public data points beyond retail pricing — useful context, not a price quote.

$17.2M
Medicare Part D spend, 2024
1.1M
Medicare Part D claims, 2024
11
FDA-listed manufacturers (Orange Book)
$4.53
Federal (VA) contract price per pack (20)

Frequently asked questions

How much does Cefuroxime Axetil cost without insurance?
Retail (no-insurance) prices we found for Cefuroxime Axetil range up to about $27.21 depending on pharmacy, form, and quantity. With a free pharmacy discount card, the lowest price we found was $14.70. Your actual price depends on the exact strength, quantity, and pharmacy — see the tables above.
Is there a generic version of Cefuroxime Axetil?
Yes — our pricing data includes at least one generic listing for Cefuroxime Axetil. Generics contain the same active ingredient and are typically the lowest-cost option; check the price tables above for the generic rows specifically.
What drug class is Cefuroxime Axetil in?
Cefuroxime Axetil belongs to the cephalosporins - 2nd generation class of antibiotics. WHO classifies it as an 'Watch' antibiotic under its AWaRe stewardship framework.

Sources

Page info

Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.