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Erythromycins WHO AWaRe: Watch Prescription only

Erythromycin (Eryped 400) — Compare Prices at US & Canada Pharmacies

Compare real Erythromycin prices at US and Canadian pharmacies, see official FDA uses and warnings, and find generic alternatives. Save up to 93% by comparing Canada pharmacy prices.

Generic name Erythromycin
US brand names
Ery-TabE.E.S.Erythrocin
Also sold as
IlosoneApo-Erythro (Canada)
Drug class
Macrolide
Typical course
7–14 daysvaries by infection
Common forms
Tablet, oral suspension, topical, ophthalmic
Generic available
Yeslow cost

How much does erythromycin cost without insurance?

Generic erythromycin is typically inexpensive with a discount card, and topical erythromycin for acne is also generally low cost. See the pharmacy-by-pharmacy pricing above for your specific form and strength.

Is there a generic version of erythromycin?

Yes — erythromycin has been generic for decades, in both oral and topical forms.

Do I need a prescription for erythromycin?

Yes for oral and prescription-strength topical forms, in both the US and Canada. (Erythromycin ophthalmic ointment for newborns is administered in-hospital, not something you buy directly.)

How can I save on erythromycin?

Compare discount-card pricing across pharmacies — as an older, well-established generic, prices are generally low but still vary by chain.

🇺🇸 United States
Lowest found, per pill
$4.36
Oral tablet/capsule, discount-card price
🇨🇦 Canada
Lowest found, per pill
$0.29
Oral tablet/capsule, USD equivalent
Canada is typically cheaper for Erythromycin Save up to 93%

"As low as" figures compare the single lowest oral tablet/capsule price found on each side — not necessarily the same strength or pack size. Always check the full tables below for your exact dose. Prices updated 2026-08-21.

Erythromycin prices at US pharmacies

(Erythromycin) — tablet, 500mg, qty 6

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $29.14 $26.14
Food Lion $44.96
Kroger Pharmacy $49.77 $46.77
Harris Teeter Pharmacy $49.77 $46.77
Walgreens $51.38 $48.38
Publix $73.13 $70.13
Costco $72.44
Walmart Neighborhood Market $82.81 $79.81

Erythromycin Base (Erythromycin) — tablet, 500mg, qty 6

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $29.14 $26.14
Food Lion $44.96
Kroger Pharmacy $49.77 $46.77
Harris Teeter Pharmacy $49.77 $46.77
Walgreens $51.38 $48.38
Publix $73.13 $70.13
Costco $72.44
Walmart Neighborhood Market $82.81 $79.81

Eryped 400 (Erythromycin Ethylsuccinate) — bottle, 100ml of 400mg/5ml, qty 100

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $83.87 $80.87
Walgreens $193.32 $190.32
Publix $248.70 $245.70
Food Lion $249.00
Walmart Neighborhood Market $284.25 $281.25
Walmart Pharmacy $284.25 $281.25
Kroger Pharmacy $357.28 $354.28
Harris Teeter Pharmacy $357.28 $354.28

(Erythromycin Ethylsuccinate) — bottle, 100ml of 200mg/5ml, qty 100

PharmacyRetail priceWith discount card
CVS Pharmacy Lowest $69.85 $66.85
Walgreens $123.89 $120.89
Kroger Pharmacy $154.71 $151.71
Harris Teeter Pharmacy $154.71 $151.71
Walmart Neighborhood Market $159.99 $156.99
Walmart Pharmacy $159.99 $156.99
Food Lion $209.00
Publix $213.15 $210.15

Erythromycin — tube, 3.5gm of 5mg/gm, qty 3.5

PharmacyRetail priceWith discount card
Walmart Neighborhood Market Lowest $12.38 $9.38
Walmart Pharmacy $12.38 $9.38
Kroger Pharmacy $15.99 $12.99
Harris Teeter Pharmacy $15.99 $12.99
Publix $21.99 $18.99
CVS Pharmacy $23.75 $20.75
Costco $21.99
Food Lion $23.08

Erythromycin prices at Canadian pharmacies

StrengthPharmacyPer pill (USD)Pack total
Default CanadianPrescriptionDrugstore.com $0.67 $200.00 / 300
Default GoldStarMeds.com $0.69 $274.20
Default GoldStarMeds.com $0.73 $219.02
Default 1800RxOnline.com $0.76 $304.67
Default 1800RxOnline.com $0.81 $243.35
StrengthPharmacyPer pill (USD)Pack total
500 mg InhalersOnline.com $0.70 $70.00 / 100
500 mg InhalersOnline.com $3.10 $30.99 / 10
StrengthPharmacyPer pill (USD)Pack total
5 mg/g SPFPharmacy.com $10.00 $105.00
5 mg/g InhalersOnline.com $11.24 $117.99
5 mg/g SPFPharmacy.com $17.14 $60.00
5 mg/g InhalersOnline.com $21.43 $74.99
StrengthPharmacyPer pill (USD)Pack total
5 mg/g (0.5%) CanadianPharmacyAdvantage.com $4.80 $50.45
5 mg/g (0.5%) CanadaPharmacies.com $5.90 $61.99
5 mg/g (0.5%) CanadianPharmacyAdvantage.com $6.45 $22.58
5 mg/g (0.5%) CanadaPharmacies.com $9.71 $33.99

Canada prices are converted to USD at time of collection and shown per tablet where available. Ordering from Canadian pharmacies is legal for personal use in most cases but subject to FDA/CBSA rules — see US vs Canada, explained.

What is Erythromycin used for?

Erythromycin was one of the first macrolide antibiotics developed and is still used today, though azithromycin and clarithromycin have largely replaced it for many respiratory infections because they're better tolerated and dosed less frequently. Where erythromycin still holds its own: it remains a standard alternative for people who can't take penicillins, it's a common topical treatment for acne (alone or combined with benzoyl peroxide), and it has a specific, well-known use as a "prokinetic" — at low doses, it can help the stomach empty faster, which is occasionally used off-label for that purpose.

The oral form has a notable downside compared to newer macrolides: it causes more GI side effects, particularly stomach cramping and nausea, which is directly related to the same stomach-emptying effect that makes it occasionally useful for that off-label purpose. Taking it with food can help, though certain formulations are specifically meant to be taken on an empty stomach — check your specific product's instructions.

It's not effective against viral infections, and it shares meaningful drug interaction risk with other macrolides due to its effect on liver drug-metabolizing enzymes.

How Erythromycin works

  1. Blocks bacterial protein production

    Erythromycin binds to the bacterial ribosome and interrupts the assembly of proteins the bacteria need to grow and function.

  2. Growth is halted (bacteriostatic)

    Susceptible bacteria stop multiplying rather than being killed outright, allowing your immune system to clear the infection.

  3. Also stimulates gut motility

    Separately from its antibiotic effect, erythromycin activates a gut hormone receptor (motilin) that speeds stomach emptying — the mechanism behind both its GI side effects and its occasional off-label use.

Typical dosage forms & strengths

UseTypical adult doseForm
Most common infections (adults)250–500 mg every 6 hours, or 333 mg every 8 hoursTablet
Acne (topical)Applied 1–2 times daily to affected skinTopical gel/solution
ChildrenWeight-based (mg/kg/day), divided dosesOral suspension

General reference dosing from the FDA label — not personalized advice. Your prescribed dose may differ based on your infection, kidney function, age, and weight. Always follow your prescriber's instructions.

Related & alternative drugs

Warnings & interactions

This is a summary of the official FDA label text, not personalized medical advice. It does not list every possible interaction or side effect. Always tell your prescriber and pharmacist about every medicine and supplement you take.

Common, usually mild

  • Stomach cramping, nausea
  • Diarrhea
  • Loss of appetite
  • Skin irritation (topical form)

Serious — seek care promptly

  • Irregular or rapid heartbeat (rare heart rhythm effect)
  • Signs of an allergic reaction: hives, facial/throat swelling, trouble breathing
  • Yellowing of skin or eyes (rare liver effect)
  • Severe or watery diarrhea (possible C. diff)

Contraindications

CONTRAINDICATIONS Erythromycin Topical Solution USP, 2% is contraindicated in those individuals who have shown hypersensitivity to any of its components.

Warnings

WARNINGS Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is one primary cause of “antibiotic-associated colitis”. After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated.

Notable drug interactions

Drug / substanceWhat can happen
StatinsCan raise statin levels, increasing muscle damage risk — similar concern to clarithromycin, though generally less pronounced.
WarfarinCan enhance anticoagulant effect; monitoring may be advised.
Other QT-prolonging drugsCombined use raises heart rhythm risk — share your full medication list with your prescriber.
TheophyllineErythromycin can raise theophylline levels; monitoring may be needed.

Pregnancy & breastfeeding

Pregnancy: Teratogenic Effects: Pregnancy Category B - There was no evidence of teratogenicity or any other adverse effect on reproduction in female rats fed erythromycin base (up to 0.25% of diet) prior to and during mating, during gestation and through weaning of two successive litters. There are, however, no adequate and well-controlled studies in pregnant women.

Erythromycin, by the numbers

Additional public data points beyond retail pricing — useful context, not a price quote.

$34.6M
Medicare Part D spend, 2024
1.5M
Medicare Part D claims, 2024
77
FDA-listed manufacturers (Orange Book)
$10.64
Federal (VA) contract price per pack (3.5GM)

Frequently asked questions

How much does Erythromycin cost without insurance?
Retail (no-insurance) prices we found for Erythromycin range up to about $357.28 depending on pharmacy, form, and quantity. With a free pharmacy discount card, the lowest price we found was $9.38. Your actual price depends on the exact strength, quantity, and pharmacy — see the tables above.
Is Erythromycin cheaper in Canada or the US?
Based on the oral tablet/capsule prices in our data, Canada was cheaper for Erythromycin — as low as $4.36/pill in the US versus $0.29/pill in Canada, a difference of about 93%. This compares the single lowest price found on each side, not necessarily the same exact strength.
Is there a generic version of Erythromycin?
Yes — our pricing data includes at least one generic listing for Erythromycin. Generics contain the same active ingredient and are typically the lowest-cost option; check the price tables above for the generic rows specifically.
What drug class is Erythromycin in?
Erythromycin belongs to the erythromycins class of antibiotics. WHO classifies it as an 'Watch' antibiotic under its AWaRe stewardship framework.

Learn more about Erythromycin

In-depth answers to common Erythromycin questions, fact-checked against the sources cited in each.

Azithromycin costs without insurance: pricing and affordability options
  • A typical five-day course of azithromycin (250 mg tablets) runs approximately $78 when purchased without insurance coverage.
  • Most major insurance programs, including Medicare Part D, Medicare Advantage plans, and Medicaid, provide coverage for azithromycin.
  • Uninsured patients can reduce out-of-pocket expenses by comparing prices across pharmacies, using pharmacy discount programs or coupons, and exploring community health resources.

Azithromycin belongs to the macrolide class of antibiotics and is prescribed to treat bacterial infections such as pneumonia, bronchitis, sinus infections, strep throat, ear infections, and certain sexually transmitted diseases. Most patients receive azithromycin as tablets taken over a short treatment window—typically just a few days. Without insurance, the cost of azithromycin can exceed that of alternative common antibiotics, making it worthwhile to understand cost-reduction strategies before having a prescription filled.

Insurance coverage for azithromycin

Major insurance carriers, including commercial health plans, Medicare Part D, Medicare Advantage, and Medicaid, typically include azithromycin in their formularies.

Azithromycin pricing without insurance

Without insurance coverage, azithromycin 250 mg tablets cost roughly $78 for a six-tablet pack (equivalent to a five-day treatment course), or approximately $13 per tablet. Insurance can reduce this amount significantly, though your actual expense will depend on your prescribed dose, treatment length, and whether you have met your deductible.

Azithromycin is the generic equivalent of the brand-name drug Zithromax, which commands a higher price. Among the most widely dispensed antibiotics, Zithromax is sold in two formats: the Z-Pak (six 250 mg tablets for five days of therapy) and the Tri-Pak (three tablets for three days). The brand-name Z-Pak typically costs about $48 per six-tablet pack without insurance.

When medically appropriate and approved by your doctor, alternative antibiotics may be suitable. These include penicillin-based drugs (such as amoxicillin), cephalosporins, tetracyclines, lincosamides, and fluoroquinolones. However, physicians rely on established clinical guidelines to select the most suitable and potent medication based on the specific pathogen and its resistance patterns. In many situations, azithromycin remains the optimal choice. If cost is a barrier to obtaining an azithromycin prescription, speak with your healthcare provider about potential alternatives.

Over-the-counter medicines and herbal supplements may ease symptoms associated with bacterial infections but cannot cure the underlying infection itself.

Drug Typical price without insurance
Azithromycin (generic, 6 tablets of 250 mg) $78
Zithromax (brand-name, 6 tablets of 250 mg) $48
Clarithromycin (generic, 28 tablets of 500 mg) $149
Erythromycin (generic, 6 tablets of 500 mg) $127
Amoxicillin (generic, 21 capsules of 500 mg) $19
Obtaining azithromycin without insurance

Filling prescriptions without insurance can strain a budget, yet azithromycin is generally an affordable generic option. Since it is typically given as a brief course rather than a long-term regimen, total expenses often remain manageable compared to other medications.

Generic drugs ordinarily lack manufacturer copay assistance, branded discount cards, or patient assistance initiatives. Nevertheless, several practical approaches can bring down your azithromycin costs without insurance.

1. Use prescription discount programs

Prescription discount programs and pharmacy coupon services can substantially lower your out-of-pocket expense for azithromycin. Many pharmacies offer promotional pricing on generic antibiotics. Search available coupons at your preferred pharmacy, and you may find azithromycin at reduced rates—for example, as low as $6 for a six-pack of 250 mg tablets or $5 for a three-pack of 500 mg tablets at certain retail chains. These programs are typically free to access and open to anyone, regardless of insurance status.

2. Compare pharmacy prices

Azithromycin pricing fluctuates significantly between pharmacies. For instance, a five-day supply could be $24 at one pharmacy and $39 at another. Taking time to check prices at different pharmacies before submitting your prescription helps ensure you pay the lowest available price.

3. Visit a community health clinic

If azithromycin remains financially out of reach, look into your local community health clinics. Many such facilities dispense medications at reduced rates or can connect you with local assistance programs offering free or discounted prescriptions. Your city or county health department can direct you to clinics operating in your area.

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Prices last checked 2026-08-21. Reviewed against FDA and DailyMed official sources — see our review process. Not a substitute for professional medical advice.