Zithromax Z Pak Over The Counter

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Zithromax Z-pak History

Zithromax Z-pak is a broad-spectrum antibiotic good against certain kind of bacteria. It injures them but requires the body’s immune system to really finish the bacteria off.

It’s not good against the common cold, the flu. Every time you have a sore throat you shouldn’t run into the doctor and get an antibiotic because it’s not going to work. In this case, Zithromax probably going to cause you some side-effects. It is also not good against allergies.

In 2010 it was the most commonly prescribed outpatient antibiotic here in the United States. If we look at all prescriptions in 2017, it was number 11. If we look at other countries, say Sweden, they rarely use it at all.

Azithromycin was developed in the late 1970s in Zagreb, Croatia. I don’t think they had a big R&D budget. They synthesized it from erythromycin. Scientists changed erythromycin and added a nitrogen, did some other kind of things. Now we know it is the Z-pak

They started off with relatively little mone, patented the drug first in Yugoslavia. Then they partnered in 1986 with the Pfizer pharmaceutical company. Pfizer brought it out here in the United States and throughout the rest of the world after 1991.

However, the Pliva pharmaceutical company retained the rights to sell it over in Eastern and Central Europe.

What Is Zithromax Used For?

It’s good against certain kind of bacteria like strep bacteria, a staph infection that sensitive to penicillin. It’s no good and, as a matter of fact, most of the staff we have nowadays is resistant to penicillin.

Zithromax is also used to treat influenza that’s very common in kids, a common cause of ear infections, throat infections.

It’s also good against Legionnaires’┬ádisease and whooping cough

It kills certain kind of anaerobic bacteria – bacteria that grow without oxygen. Unfortunately, they constitute the mass of intestinal and vaginal organisms. So, when you take this drug it’s not uncommon to get GI problems and also a vaginitis.

Zithromax shows great results against the organism that causes community-acquired pneumonia. We call that chlamydia pneumonia. And it’s good against chlamydia you get in your genital tract and certain other kinds of organisms that cause genital infections.

Don’t people tell you to use it for strep throat or bronchitis certain kind of skin infections, or maybe even traveler’s diarrhea.

People who are going to the dentist might take 30 to 60 minutes before the procedure in order to prevent an infection in the heart.

Once upon a time it was very commonly used for syphilis. Now it’s not very commonly used for gonorrhea but now gonorrhea is resistant oftentimes to antibiotics. If you’re going to treat a person with gonorrhea, it takes a shot of ceftriaxone, the different kinds of antibiotic and then some Zithromax.

Z-Pak also might help prevent certain kind of bacterial infection in the lung of HIV-positive patients. The government says that it’s pretty good to help treat and maybe even prevent some of the acute bacterial exacerbations or flares of chronic obstructive lung disease, the people who were once upon a time smokers get. Especially if they’re due to those organisms that I just mentioned.

Zithromax might be also good for acute sinusitis if it happens to be bacterial in origin but probably not as good as Augmentin.

It is a good drug to mention for treatment of certain kind of pneumonia, uncomplicated skin infections, acute middle ear infections. But it’s probably not the first choice, Amoxicillin is used more often.

For that and for either pharyngitis or tonsillitis it is probably not the first line drug, but it’s still an acceptable treatment for people who get urethritis or cervicitis inflammation of the urethra or the cervix typically from chlamydia.

Zithromax can be used for gonorrhea but in 2015 we noticed a remarkably highly resistant strain of gonorrhea. That’s why you have to get the shot of Ceftriaxone in addition.

If a person has been sexually assaulted this is a good antibiotic in combination with that Ceftriaxone to hopefully help prevent any sequences of that sexual assault.

How To Take Zithromax

It’s an acid stable antibiotic. That is why you can take it with or without food, doesn’t seem to make much difference. Except if you’re going to take the sustained-release oral suspension then you shouldn’t have any food within two hours of it.

It’s rapidly absorbed from the gut into the blood with about 30-40% of it actually gets into the blood. Once it’s in, it seems to peak at about 2 to 3 hours if you take the immediate release in and about 5 hours if you take a sustained release and stays in your body for somewhere between 2-3.5 days.

Zithromax comes in multiple different forms, You can take it as a film-coated tablet or you can take it as a capsule or a suspension. You can also get it a little package that you dissolve in water. It also comes in a suspension either one that’s immediately released or delayed release. The two can’t be used interchangeably. It also comes as an ophthalmic medication at the present time.

If you happen to have either some degree of kidney function or liver malfunction, still okay to take the drug because it’s not metabolized in the body. It actually goes out principally through the liver into the bile and is excreted in the bowels unchanged. About 5-10% goes out in the urine unchanged.

Once the drug is in the bloodstream, it seems to concentrate in the phagocytes. Phagocytes are a type of white blood cell to go and attack bacteria. It’s good that they’re attracted to the phagocytes because with the phagocytes do is they go right to the site of infection and concentrate the antibiotic. The antibiotic at the site of infection can be 50 times greater in concentration than it is in the bloodstream. Then after it has done its job it just slowly dissolves back into the blood that’s why it takes so long to get out.

Zithromax seems to penetrate the tissues very well, doesn’t matter whether we’re talking about the bone of the stomach or the uterus of the gallbladder.

Interestingly, if you happen to be allergic to either Azithromycin or Clarithromycin, you shouldn’t take this drug because there’s interaction, Obviously, since it’s related to erythromycin if you have an organism that is not capable of being treated with erythromycin this one didn’t go work either.

You don’t have to worry about a lot of drug side effects. You shouldn’t take it with certain older HIV treating drugs. Zithromax changes the effect of Warfarin on your body for the most part.

Typical Z-pak comes either three-day or five-day, the standard is 5-day. The 5-day is 250 milligrams, you take two pills day one and then you take one pill 250 milligrams on day 2, 3, 4 and 5.

Some people opt for and in certain conditions, it’s acceptable to buy Zithromax 500 milligrams each day for 3 days. Unusually, for genital infections, you would take a 1000 milligrams at one time or for gonorrhea some people go to 1000 milligrams at one time.

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How Does Zithromax Work Compared To Other Antibiotics?

It works pretty well if we’re talking about the susceptible organism.

Let’s say you have chronic lung disease. Does it work as well as, say Biaxin? Yes, pretty much. The difference is that Biaxin is taken 2 times a day and you have to do it for 10 days. If you took the azithromycin, you could take five days Z Pak and that seems to work.

You can also buy Zithromax 3-day Z Pak or you could take 500 milligrams once a day for three days for a bacterial sinusitis.

Zithromax works about as well as the Augmentin. But again, the Augment you have to take several times a day for ten days as opposed to say a 3-day course of the Z-Pak.

If you happen to have community-acquired pneumonia, that’s an otherwise healthy individual who just gets pneumonia, you can take azithromycin except if you’re elderly, debilitated or your immune system doesn’t work. Because remember, the immune system is required to wipe up the bacterial organisms that are just injured by the antibiotic.

If you get your pneumonia while you’re in the hospital, if you have cystic fibrosis or if you have bacteria in the bloodstream this isn’t the one for you, take a more potent drug.
Does Zithromax Have Side Effects?

You bet it does. The side effects tend to be concentrated around the gastrointestinal system.

If you take the drug you have a 30-50% chance of having nausea, vomiting, horrible diarrhea, abdominal pain, upset stomach, dyspepsia gas.

If your woman you may have some vaginitis. Anyone can get some malaise. You don’t feel well, you can have an allergic reaction to it, you get nervous.

Interestingly, we’ve just recently learned that some people who take it have hearing loss or they develop ringing in the ears. Some people can develop a horrible skin reaction that can go on to precipitate death something called the Stevens-Johnson syndrome or Cox epidermal necrolysis.

Fortunately, it is very rare but it can cause you to become sensitive to the sun. And because it kills the good bacteria in your gut it can cause an overgrowth of Clostridium difficile that can lead to horrible problems and even lead to death.

It will say on the prescription that caution if you’re taking an antibiotic but it doesn’t interact with the antibiotics. Even though the drugs been available since 1971, the FDA did not until 2017 add a warning that if it’s given to kids within the first six weeks of life that might cause a blockage between the stomach and the intestine, something we call pyloric stenosis.

In 2017 they also added the warning for the hypersensitivity reactions, severe allergies. But in 2013 FDA said people who take the drug might have certain kind of electrical abnormalities of the heart that can lead to potentially fatal ventricular arrhythmias. In other words, you die from heart attack, heart disease or sudden cardiac death if you take the drug.

In 2012 study published in the New England Journal of Medicine where they looked at the Tennessee Medicaid recipients and they looked at the people who took antibiotics and didn’t take antibiotics. Then the scientists compared drugs like Amoxicillin and Cipro to the Zithromax Z Pak.

What they found was that the people who take Zithromax had about a three-fold increase in their risk of death during the time they were taking the drug, They divided it into people who had an average risk for heart disease, low risk for heart disease or high risk for heart disease.

Actually, founded per million courses there were nine people who died if they were below risk for heart disease, 45 people who died if they were at average risk. But if they were at above risk 245 people died from sudden cardiac death. That’s the warning that you have to pay attention to who’s most at risk. These are people who have a heart problem, people who have very slow heart rates, who have an electrocardiograph abnormality that tends to run in the families or may be caused by certain kinds of drugs called a long QT syndrome or prolonged QT interval.

The government also says that if you take the drug, you might develop hepatitis, hepatic necrosis, hepatic failure or you might die of liver disease, They also say that peculiarly it might somehow be associated with myasthenia gravis where the nerves don’t tell the muscles how to work properly.

How Does Zithromax Work?

The drug interacts with something known as ribosomal RNA and that prevents the protein synthesis that’s necessary for the bacteria to grow. It doesn’t inhibit their nucleic acid synthesis, but it just injures them by preventing some of the protein.

Yet also more recently has been found to work on the body’s immune system. Azithromycin interferes with something called quorum sensing, which is a condition where the bacteria depending on the number of bacteria and the interactions they have. Like humans when we’re in a society versus when we by ourselves we do things differently.

Well, quorum sensing is the turning on or turning off of bacterial genes. When you turn on some of the genes that are typically off then the bacteria can form biofilms. Biofilms are sort of like a saran wrap that develops in tissue. The bacteria can live in the tissue and then the body’s antibodies from the inside can’t kill them and the antibiotics you take from the outside can be killed them.

It is very important and remembers this is a bacteriostatic drug. It injures but doesn’t kill the bug. It requires the body’s immune system to take control of it except in those instances where it really is highly concentrated as it is in some infections because it’s taken in there by the phagocytes.

The good news is that it doesn’t seem to interact with a lot of other drug metabolisms. You don’t have to worry about when you take too many other kinds of drugs except warfarin. But if you’re going to take an antacid, stay away from the drug for at least two hours either before or after.

How Much Does Zithromax Cost?

The real good news is that while the brand-name Zithromax is going to cost you about 200 bucks or more. If you pay cash for the generic Zithromax, it’s only going to cost you about 20-40 dollars for a course.

If you go to a place like Good RX and get a free coupon, it might even be cheaper than using your insurance and then it only cost you about 10 to 20 dollars.

Remember, Zithromax Z Pak is a good antibiotic if we’re talking about treating bacterial infections, not the common cold, not a virus.

If we’re talking about bacterial infection caused by a susceptible bacteria, this is a relatively good drug but it’s going to cause a lot of gastrointestinal side effects. If you’re a woman they cause some vaginitis as well. And because we overuse the drug so much, there’s a lot of bacterial resistance that’s developing. Do be careful.